The comparison of percent free PSA with total PSA in the diagnosis of prostate Cancer. | [Journal of Pakistan Medical Association • 2003]

Author(s):

1. T. Rafi: Armed Forces Institute of Pathology, Rawalpindi, Pakistan

2. A Satar: Armed Forces Institute of Pathology, Rawalpindi, Pakistan

3. N. Asif: Armed Forces Institute of Pathology, Rawalpindi, Pakistan

4. M. M. Dawood: Armed Forces Institute of Pathology, Rawalpindi, Pakistan

5. M. Aamir: Armed Forces Institute of Pathology, Rawalpindi, Pakistan

Abstract:

To determine the ratio of free to total PSA in patients of carcinoma prostate and nodular hyperplasia, and to compare this ratio with total PSA for diagnosis of prostrate cancer. The study was conducted in Armed Forces Institute of Pathology (AFIP) Rawalpindi in collaboration with Armed Forces Institute of Urology (AFIU) Rawalpindi, over a period of 7 months (February 2000 to August 2000). One hundred and seventy nine blood samples were collected from patients admitted for prostatectomy. After surgery, diagnosis of prostate carcinoma or nodular hyperplasia was confirmed histologically. Serum samples were analyzed for total and free PSA. The 2SD values of total PSA for nodular hyperplasia were 4.07-13.93 ng/ml (mean = 9.00 ng/ml), and for carcinoma prostate were 9.34-23.74 ng/ml (mean = 16.54 ng/ml). These values showed a considerable overlap. While 95 % confidence interval values of percent free PSA for nodular hyperplasia were 14.00 -28.08% (average = 21.04%), and for carcinoma prostate were 2.69-16.05% (average = 9.37%) and these values showed a little overlap. The sensitivity of percent free PSA in differentiating between prostate carcinoma and nodular hyperplasia was 96% with a cut off limit of 15% of % free PSA as compared to 74 % with total PSA alone. Percent free PSA is a better marker for differentiating patients of carcinoma prostate from nodular hyperplasia as compared to total PSA.

Page(s): 229-232

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 53, Issue: 6, Year: 2003

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