A review on Biotransformational Studies of Danazol. | [Pakistan Journal of Biotechnology • 2017]

Author(s):

1. Azizuddin: Department of Chemistry, Federal Urdu University of Arts, Science & Technology, Gulshan-e-Iqbal Campus, Karachi, Pakistan

Abstract:

Biotransformation is the basis of life. Various chemical modifications are occurred by drugs in the body to give metabolites as new molecules having their own features, generally different from those of drug. Danazol (1) is used more effectively for the treatment of endometriosis and benign fibrocystic mastitis. As a result of biotransformation of danazol (1) variety of metabolites, 2-17 were identified by using different sources including a monkey, human (male and female) volunteers and horse, and fermentation with Cephalosporium aphidicola, Aspergillus niger, Fusarium lini, Fusarium solani, Gibberella fujikuorii and Bacillus cerus. This present review will discuss metabolites 2-17, obtained from danazol (1) up to 2012.

Page(s): 833-838

DOI: DOI not available

Published: Journal: Pakistan Journal of Biotechnology, Volume: 14, Issue: 4, Year: 2017

Keywords:

Keywords are not available for this article.

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