An Experimental Study on the Treatment of Diabetes-induced Cognitive Disorder Mice Model with Exosomes Deriving from Mesenchymal Stem Cells (MSCs). | [Pakistan Journal of Pharmaceutical Sciences • 2019]

Author(s):

1. Wenjing Zhao: Neurology Department No.1, Affiliated Hospital of Hebei University of Engineering, Handan, China

2. Haifang Zhang: Handan Emergency Rescue Command Center, Handan, China

3. Jilin Yan: Neurology Department No.1, Affiliated Hospital of Hebei University of Engineering, Handan, China

4. Xiaohong Ma: Department of Neurology, Xinxiang Central Hospital, Xinxiang, China

Abstract:

The occurrence rate of senile dementia among diabetes patients is high, but there is still no effective therapeutic method. This study aimed to explore curative effect of exosomes deriving from MSCs treating diabetesinduced cognition impairment. After BM-MSCs culture was purified, Western Blot and electron microscope were used to identify exosomes which were injected into diabetes mouse through intracranial injection. Purified exosomes in Western blot analysis and electron microscope observation were verified. After therapy with exosomes deriving BMMSC, mouse cognition impairment and histologic abnormity were recovered. Exosomes deriving from BM-MSCs can be a new preparation treating cognition with application prospect.

Page(s): 1965-1970

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 32, Issue: 5, Year: 2019

Keywords:

exosome , cognition impairment , Mesenchymal stem cells MSCs

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