The Association Between Facial Ageing and Bone Mineral Density: A Mendelian Randomisation Study | [Journal of the College of Physicians and Surgeons Pakistan • 2025]

Author(s):

1. Yabo Wang: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, China;Department of Emergency, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, China

2. Chao Zhen: Department of Neurology, Qingdao Municipal Hospital, University of Health and Rehabilitation Sciences, Qingdao, China

3. Ziyu Wang: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, China

4. Lu Zhang: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, China

5. Yunzhen Chen: Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, China

Abstract:

This article aimed to assess the causative association between facial ageing and bone mineral density (BMD) using Mendelian randomisation (MR). In this observational study, single-nucleotide polymorphisms (SNPs) linked to facial ageing and four di erent body regions, including total mineral density (TB-BMD, n = 56,284), femoral neck BMD (FN-BMD, n = 32,735), forearm BMD (FABMD, n = 8,143), and lumbar spine BMD (LS-BMD, n = 28,498), were employed as instrumental variables. A two-sample MR analysis was undertaken to scrutinise the causal association between the identi ed exposure and respective outcomes. The authors found there was no causal relationship between facial ageing and TB-BMD (Beta, -0.1238; 95% CI, -0.3125 to 0.0648; p = 0.1982), FN-BMD (Beta, 0.0720; 95% CI, -0.1728 to 0.3168; p = 0.5643), FA-BMD (Beta, 0.0582; 95% CI, -0.3803 to 0.4966; p = 0.7949), or LS-BMD (Beta, -0.0188; 95% CI, -0.3087 to 0.2711; p = 0.8987). Therefore, the degree of osteoporosis in a person cannot be inferred based on their facial ageing.

Page(s): 797-799

DOI: 10.29271/jcpsp.2025.06.797

Published: Journal: Journal of the College of Physicians and Surgeons Pakistan, Volume: 35, Issue: 06, Year: 2025

Keywords:

Bone Mineral Density , Osteoporosis , causal relationship , Mendelian randomisation , Facial ageing

References:

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