The Influence of Genetic Markers on the Development of Mental Disorders: A Systematic Review of Studies | [Journal of Pioneering Medical Sciences • 2024]

Author(s):

1. Maiia Melnychuk: Department of Psychology, Faculty of Psychology and Social Work, Poltava V.G. Korolenko National Pedagogical University,Poltava,Ukraine

2. Mykhailo Zhylin: Department of Practical Psychology, Odesa National Maritime University,Odesa,Ukraine

3. Nataliia Makarchuk: Department of General and Practical Psychology, Faculty of Administration, Management and Information Activities, Izmail State Humanities University,Izmail,Ukraine

4. Kateryna Sakharova: Department of Psychology and Pedagogy, Dnipropetrovsk State University of Internal Affairs,Dnipro,Ukraine

5. Yaroslava Shven: Ukraine Gothenburg, Gothenburg, Sweden

Abstract:

Introduction: The etiology of mental disorders is largely influenced by genetic elements. Several studies have shown that genetic elements influence major mental disorders (MDs). However, the quantity and type of the genetic input remain unknown and require further research. Objective: In this review, we aim to investigate the impact of genetic markers on the development of mental disorders. Methodology: In our study, we included English studies from online databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library using the following keywords “genetic factors”, “genetic markers”, “mental disorders”, “anxiety”, “depression”, and “schizophrenia” till March 2024. Results: The result of the search utilizing the strategy of our search was 2107 studies. We selected the articles that were relevant to our topic by screening these articles. After eliminating the remaining papers based on title and abstract screening, we conducted a full-text screening of 318 publications. In the end, we consulted 68 articles to learn more about our subject and compose this evaluation. Scientific Novelty: Most of the previous studies discovered that genetic elements contribute to major MDs. However, the nature and extent of the genetic contribution have not been determined. In our review, we discussed the genetic contribution to the occurrence of MDs. Practical Significance of the Results Obtained: The influence of genetic research on individuals with MDs and their families was one of our review's main concerns. Understanding the extent of genetic elements' contribution to MDs may have implications for society, research, patient outcomes, and quality of life. Conclusion: This comprehensive study demonstrates that the development and onset of MDs are affected by several elements, which can be genetic polymorphisms and genetic mutations. The potentiality of genetics studies to detect the occurrence of MDs may help in the early recognition of these conditions. It could assist in identifying people who are more susceptible to developing specific disorders according to their genetic profile.

Page(s): 30-37

DOI: 10.61091/jpms202413306

Published: Journal: Journal of Pioneering Medical Sciences, Volume: 13, Issue: 3, Year: 2024

Keywords:

Neuropsychiatric disorders , Biomarkers , Psychiatry , genetic factor , mds

References:

[1] Gelsanda C. I.,Marchianti A. C. N.,Nurdian Y. .2024 .The Relationship Between Well Water Quality and Cognitive Function in Well Water Users. Futurity Medicine, 3(2) : 27-37.

[2] Sabri B.,Greene M. C.,Du S.,Solomon S. S.,Srikrishnan A. K.,Mehta S. H.,Lucas G. M. .2023 .Exploring multilevel determinants of co-occurring violence, HIV, mental health and substance use problems. Journal of Ethnic & Cultural Diversity in Social Work, 32(4) : 210-222.

[3] S KI. .2023 .The role of robotics and automation in surgery: Critical review of current and emerging technologies. Futurity Medicine, : 23-35.

[4] Andrade-Guerrero J.,Santiago-Balmaseda A.,Jeronimo-Aguilar P.,Vargas-Rodríguez I.,Cadena-Suárez A. R.,Sánchez-Garibay C.,Soto-Rojas L. O. .2023 .Alzheimer's Disease: An updated overview of its genetics. International Journal of Molecular Sciences, 24(4) : 3754.

[5] Hoang Nguyen,Duong Nguyen .2024 .Factors affecting the financial performance of banks in the era of digital transformation: A perspective from Vietnam's banking industry. Futurity Economics, : 4-30.

[6] Borsboom D. .2017 .A network theory of mental disorders. World Psychiatry, 16(1) : 5-13.

[7] Schuch F. B.,Vancampfort D. .2021 .Physical activity, exercise, and mental disorders: It is time to move on. Trends in Psychiatry and Psychotherapy, 43 : 177-184.

[8] Gunin A. .2024 .The future of mortgage financing in the era of fintech: A systematic review. Futurity Economics, : 31-47.

[9] Yan W. J.,Ruan Q. N.,Jiang K. .2022 .Challenges for artificial intelligence in recognizing mental disorders. Diagnostics, 13(1) : 2.

[10] Dai X. J.,Shao Y.,Ren L.,Tao W.,Wang Y. .2022 .Risk factors of COVID-19 in subjects with and without mental disorders. Journal of Affective Disorders, 297 : 102-111.

[11] Gilbert R. .2023 .Mental disorders. International Journal of Philosophical Practice, 9(1) : 74-88.

[12] Sacco R.,Camilleri N.,Eberhardt J.,Umla-Runge K.,NewburyBirch D. .2022 .A systematic review and meta-analysis on the prevalence of mental disorders among children and adolescents in Europe. European Child & Adolescent Psychiatry., : .

[13] Yoo T. K.,Han K. D.,Rhee E. J.,Lee W. Y. .2023 .Impact of mental disorders on the risk of heart failure among Korean patients with diabetes: A cohort study. Cardiovascular Diabetology, 22(1) : 115.

[14] Kazdin A. E.,Wu C. S.,Hwang I.,Puac-Polanco V.,Sampson N. A.,Al-Hamzawi A.,Kessler R. C. .2023 .Antidepressant use in low, middle-, and high-income countries: A World Mental Health Surveys report. Psychological Medicine, 53(4) : 1583-1591.

[15] Nampijja M.,Sembajjwe W.,Mpairwe H.,Mpango R.,Kinyanda E. .2022 .Prevalence and correlates of neurocognitive impairment and psychiatric disorders among schoolchildren in Wakiso District, Uganda: A cross-sectional study. Wellcome Open Research, 6 : 217.

[16] Mereniuk K.,& IP,Khrystyna. IP .2024 .MEDII AEVI in Ukrainian School textbooks: Modern paradigms and contextual analysis. Futurity Social Sciences, : 4-27.

[17] Grunberg D.,Martin J. A.,Cryan J. F.,O'Halloran K. D.,Kelleher E.,Dinan T. G.,Clarke G. .2021 .The effect of exercise interventions on inflammatory markers in major depressive disorder: Protocol for a systematic review and meta-analysis. HRB Open Research, 4 : 42.

[18] Ali Wajid,Khan Wajid .2024 .Relationship among secondary school students' physics academic achievement scores, conceptual knowledge and problem-solving skills. Futurity Social Sciences, : 56-71.

[19] Santamaría Zúñiga,Yescas T.,Gómez T.,Fricke P.,Galindo P.,I. P.,González González,M. González,Vázquez Ortega,López López A.,M. A. .2022 .Pharmacogenetic studies in Alzheimer disease. Neurología (English Edition), 37(4) : 287-303.

[20] Lin F. .2024 .The two philosophical thoughts of pluralism - Hegel and Wittgenstein's reflections on pluralism. Futurity Philosophy, : 4-22.

[21] Yi E. H. G.,Adamek M. E. .2021 .Alzheimer's caregivers' experience with and perceptions of the Affordable Care Act: Thematic analysis of online discussion forums. Journal of Applied Gerontology, 40(12) : 1796-1806.

[22] Owlett L.,Belcher E. K.,Dionisio-Santos D. A.,Williams J. P.,Olschowka J. A.,O'Banion M. K. .2020 .Space radiation does not alter amyloid or tau pathology in the 3xTg mouse model of Alzheimer's disease. Life Sciences in Space Research, 27 : 89-98.

[23] Badour C. L.,Tipsword J. M.,Jones A. C.,McCann J. P.,Fenlon E. E.,Brake C. A.,Adams T. G. .2023 .Obsessive-compulsive symptoms and daily experiences of posttraumatic stress and mental contamination following sexual trauma. Journal of Obsessive-Compulsive and Related Disorders, 36 : 100767.

[24] Storozhyk M. .2024 .Philosophy of future: Analytical overview of interaction between education, science, and artificial intelligence in the context of contemporary challenges. Futurity Philosophy, : 23-47.

[25] Perkes I. E.,Morris R. W.,Griffiths K. R.,Quail S.,Waters F.,O'Brien M.,Balleine B. W. .2022 .The motivational determinants of human action, their neural bases and functional impact in adolescents with obsessive-compulsive disorder. Biological Psychiatry Global Open Science, 3(4) : 1062-1072.

[26] Miquel-Giner N.,Vicent-Gil M.,Martínez-Zalacaín I.,Porta-Casteras D.,Mar L.,López-Solà M.,López-Solà C. .2022 .Efficacy and fMRI-based response predictors to mindfulness-based cognitive therapy in obsessive-compulsive disorder: Study protocol for a randomised clinical trial. , : .

[27] Garner A. R.,Stuart G. L. .2023 .Integrating mindfulness and acceptance into traditional cognitive behavioral therapy during the COVID-19 pandemic: A case study of an adult man with generalized anxiety disorder. Clinical Case Studies, 22(2) : 120-137.

[28] Liu C. H.,Koire A.,Feldman N.,Erdei C.,Mittal L. .2022 .COVID19-related health worries and generalized anxiety symptoms: Higher risks in perinatal women without a pre-existing generalized anxiety diagnosis. Psychiatry Research, 317 : 114918.

[29] Alnamnakani M.,Alenezi S.,Temsah H.,Alothman M.,Murshid R. E.,Alonazy H.,Alqurashi H. .2022 ./clinical-practice-and-epidemiology-in-mental-health. Clinical Practice and Epidemiology in Mental Health, 18(1) : .

[30] Shoeibi A.,Ghassemi N.,Khodatars M.,Moridian P.,Khosravi A.,Zare A.,Rajendra Acharya U. .2023 .Automatic diagnosis of schizophrenia and attention deficit hyperactivity disorder in rs-fMRI modality using convolutional autoencoder model and interval type-2 fuzzy regression. Cognitive Neurodynamics, 17(6) : 1501-1523.

[31] Williams J. C.,Tubiolo P. N.,Luceno J. R.,Gil R. B.,Girgis R. R.,Slifstein M.,Van Snellenberg J. X. .2023 .Medial prefrontal cortex dysfunction mediates working memory deficits in patients with schizophrenia. Biological Psychiatry Global Open Science, 3(4) : 990-1002.

[32] Caseras X.,Legge S. E.,Bracher-Smith M.,Anney R.,Owen M. J.,Escott-Price V.,Kirov G. .2023 .Copy number variants increasing risk for schizophrenia: Shared and distinct effects on brain morphometry and cognitive performance. Biological Psychiatry Global Open Science, 3(4) : 902-911.

[33] Thompson L. I.,Cummings M.,Emrani S.,Libon D. J.,Ang A.,Karjadi C.,Liu C. .2024 .Digital Clock Drawing as an Alzheimer's Disease Susceptibility Biomarker: Associations with Genetic Risk Score and APOE in Older Adults. The Journal of Prevention of Alzheimer's Disease, 11(1) : 79-87.

[34] Talyansky S.,Le Guen Y.,Kasireddy N.,Belloy M. E.,Greicius M. D. .2023 .APOE-ϵ 4 and BIN1 increase risk of Alzheimer's disease pathology but not specifically of Lewy body pathology. Acta Neuropathologica Communications, 11(1) : 149.

[35] Zheng X.,Wang S.,Huang J.,Li C.,Shang H. .2024 .Predictors for survival in patients with Alzheimer's disease: A large comprehensive meta-analysis. Translational Psychiatry, 14(1) : 184.

[36] Kendler K. S.,Ohlsson H.,Sundquist E. K.,Edwards J.,Sundquist A. C.,K. A. C. .2023 .Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death: A Swedish national study. Psychological Medicine, 53(4) : 1639-1648.

[37] Priya I.,Arora M.,Singh H.,Sharma I.,Mahajan R.,Kapoor N. .2022 .Genetic evidence for association of NOTCH4 variant rs2071287 with schizophrenia susceptibility in the North Indian population. Indian Journal of Psychiatry, 64(6) : 567.

[38] Szczepankiewicz A.,Rodziewicz A.,Pawlak J.,Narozna B.,Rajewska-Rager A.,Wilkosc M.,Twarowska-Hauser J. .2014 .FKBP5 polymorphism is associated with major depression but not with bipolar disorder. Journal of Affective Disorders, 164 : 33-37.

[39] Fabbri C.,Corponi F.,Albani D.,Raimondi I.,Forloni G.,Schruers K.,Serretti A. .2018 .Pleiotropic genes in psychiatry: Calcium channels and the stress-related FKBP5 gene in antidepressant resistance. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 81 : 203-210.

[40] Zobel A.,Schuhmacher A.,Jessen F.,Höfels S.,Von Widdern O.,Metten M.,Schwab S. G. .2010 .DNA sequence variants of the FKBP5 gene are associated with unipolar depression. International Journal of Neuropsychopharmacology, 13(5) : 649-660.

[41] Lekman M.,Laje G.,Charney D.,Rush A. J.,Sorant A. F.,Paddock A. J.,S. A. J. .2008 .The FKBP5-gene in depression and treatment response-an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR* D) Cohort. , 63(12) : 1103-1110.

[42] Kirchheiner J.,Lorch R.,Lebedeva E.,Seeringer A.,Roots I.,Sasse J.,Brockmöller J. .2008 .Genetic variants in FKBP5 affecting response to antidepressant drug treatment. Pharmacogenomics, 9(7) : 841-846.

[43] Dam H.,Buch J. O. D.,Nielsen A. B.,Weikop P.,Werge T.,Jørgensen M. B. .2019 .Clinical association to FKBP5 rs1360780 in patients with depression. Psychiatric Genetics, 29(6) : 220-225.

[44] Lima M. O.,Saraiva L. C.,Ramos V. R.,Oliveira M. C.,Costa D. L.,Fernandez T. V. .2024 .Clinical characteristics of probands with obsessive-compulsive disorder from simplex and multiplex families. Psychiatry Research, 331 : 115627.

[45] Lee P. H.,Anttila V.,Won H.,Feng Y. C. A.,Rosenthal J.,Zhu Z.,Burmeister M. .2019 .Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders. Cell, 179(7) : 1469-1482.

[46] Schork A. J.,Won H.,Appadurai V.,Nudel R.,Gandal M.,Delaneau O.,Werge T. .2019 .A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience, 22(3) : 353-361.

[47] Cooper R. .2017 .Diagnostic and statistical manual of mental disorders (DSM). Knowledge Organization, 44(8) : 668-676.

[48] Zhuo C.,Hou W.,Li G.,Mao F.,Li S.,Lin X.,L. X. .2019 .The genomics of schizophrenia: shortcomings and solutions. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 93 : 71-76.

[49] Wang Q.,Chen Q.,Wei Q.,Ji Y.,Yang H.,Li B. .2019 .A Bayesian framework that integrates multi-omics data and gene networks predicts risk genes from schizophrenia GWAS data. Nature Neuroscience, 22(5) : 691-699.

[50] Ikeda M.,Takahashi A.,Kamatani Y.,Momozawa Y.,Saito T.,Kondo K.,Iwata N. .2019 .Genome-wide association study detected novel susceptibility genes for schizophrenia and shared transpopulations/diseases genetic effect. Schizophrenia Bulletin, 45(4) : 824-834.

[51] Zhao X.,Huang Y.,Chen K.,Li D.,Kan C.,Q. C. .2015 .The brain-derived neurotrophic factor Val66Met polymorphism is not associated with schizophrenia: An updated meta-analysis of 11,480 schizophrenia cases. Psychiatry Research, 225(1-2) : 217-220.

[52] Jonaitis E. M.,Koscik R. L.,La Rue A.,Johnson S. C.,Hermann B. P.,Sager M. A. .2015 .Aging, practice effects, and genetic risk in the Wisconsin registry for Alzheimer's prevention. Clinical Neuropsychology, 29(4) : 426-441.

[53] Adrovic A.,Yildiz M.,Köker S.,Barut K.,Kasapçopur Ö. .2020 .Biologics in juvenile idiopathic arthritis-main advantages and major challenges: A narrative review. Archives of Rheumatology., : .

[54] Porter T.,Burnham S. C.,Milicic L.,Savage G.,Maruff P.,Lim Y. Y. .2018 .Utility of an Alzheimer's disease riskweighted polygenic risk score for predicting rates of cognitive decline in preclinical Alzheimer's disease: a prospective longitudinal study. Journal of Alzheimer's Disease, 66(3) : 1193-1211.

[55] Darst B. F.,Koscik R. L.,Racine A. M.,Oh J. M.,Krause R. A.,Carlsson C. M.,Engelman C. D. .2017 .Pathway-specific polygenic risk scores as predictors of amyloid-β deposition and cognitive function in a sample at increased risk for Alzheimer's disease. Journal of Alzheimer's Disease, 55(2) : 473-484.

[56] Ogonowski N. S.,García-Marín L. M.,Fernando A. S.,Flores-Ocampo V.,Rentería M. E. .2024 .Impact of genetic predisposition to late-onset neurodegenerative diseases on early life outcomes and brain structure. Translational Psychiatry, 14(1) : 185.

[57] Chang C. M.,Chen W. H.,Tsai M. H.,Su C. F.,Li T. P.,Bai C. T.,Y. M. C. T. .2018 .Co-aggregation of major psychiatric disorders in individuals with first-degree relatives with schizophrenia: a nationwide population-based study. Molecular Psychiatry, 23(8) : 1756-1763.

[58] Wang H. E.,Bai C. M.,Hsu Y. M.,Huang J. W.,Su K. L.,Chen T. P.,M. H. T. P. .2022 .Familial coaggregation of major psychiatric disorders in first-degree relatives of individuals with autism spectrum disorder: a nationwide population-based study. Psychological Medicine, 52(8) : 1437-1447.

[59] Chen M. H.,Hsu J. W.,Huang K. L.,Su T. P.,Li C. T.,Lin W. C.,Bai Y. M. .2019 .Risk and coaggregation of major psychiatric disorders among first-degree relatives of patients with bipolar disorder: a nationwide population-based study. Psychological Medicine, 49(14) : 2397-2404.

[60] Chen M. H.,Pan T. L.,Huang K. L.,Hsu J. W.,Bai Y. M.,Su T. P.,Chen T. J. .2019 .Coaggregation of major psychiatric disorders in first-degree relatives of individuals with attention-deficit/hyperactivity disorder: A nationwide population-based study. The Journal of clinical psychiatry, 80(3) : 11619.

[61] Sánchez X. C.,Helenius D.,Bybjerg-Grauholm J.,Pedersen C.,Hougaard D. M.,Børglum A. D.,Werge T. .2022 .Comparing copy number variations in a Danish case cohort of individuals with psychiatric disorders. JAMA psychiatry, 79(1) : 59-69.

[62] Kushima I.,Nakatochi M.,Aleksic B.,Okada T.,Kimura H.,Kato H.,Ozaki N. .2022 .Cross-disorder analysis of genic and regulatory copy number variations in bipolar disorder, schizophrenia, and autism spectrum disorder. Biological psychiatry, 92(5) : 362-374.

[63] Cuzzoni E.,De Iudicibus S.,Bartoli F.,Ventura A.,Decorti G. .2012 .Association between Bcl I polymorphism in the NR3C1 gene and in vitro individual variations in lymphocyte responses to methylprednisolone. British Journal of Clinical Pharmacology, 73(4) : 651-655.

[64] Kang H. J.,Park Y.,Yoo K. H.,Kim K. T.,Kim E. S.,Kim J. W.,Kim J. M. .2020 .Sex differences in the genetic architecture of depression. Scientific Reports, 10(1) : 9927.

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