The Insulin: Glucagon Ratio and Obesity | [Journal of Pakistan Medical Association • 2023]

Author(s):

1. Sanjay Kalra: Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India

2. Saurabh Arora: Department of Endocrinology, Dayanand Medical College, Ludhiana, Punjab, India

3. Nitin Kapoor: Department of Endocrinology, Diabetes and Metabolism Christian Medical College & Hospital, Vellore, Tamil Nadu, India; Non communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia

Abstract:

This communication discusses the physiology and pathology of the insulin glucagon ratio, with respect to obesity. Though high insulin levels are associated with obesity in this manuscript the authors specifically highlight its role in the causation and clinical management of obesity. It suggests that the term insulin glucagon ratio be used in preference to glucagon insulin ratio, and shares insights which may be helpful in informing future research.

Page(s): 709-710

DOI: 10.47391/JPMA.23-20

Published: Journal: Journal of Pakistan Medical Association, Volume: 73, Issue: 3, Year: 2023

Keywords:

Obesity , Diabetes , Overweight , Diabetes , metabolic fulcrum , ominous octet of obesity , metabolic seesaw

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