The effect of thyroid autoantibody on assisted reproduction technology outcome in euthyroid women: One center experience | [Pakistan Journal of Pharmaceutical Sciences • 2021]

Author(s):

1. Lili Zhuang: Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao University,Yantai, Shandong,China

2. Xiaoyan Liu: Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao University,Yantai, Shandong,China

3. Jianxiang Cong: Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao University,Yantai, Shandong,China

4. Ning Zhang: Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao University,Yantai, Shandong,China

5. Qinglan Qu: Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao University,Yantai, Shandong,China

6. Cuifang Hao: Reproductive Medicine Centre, Yuhuangding Hospital of Yantai, Affiliated Hospital of Qingdao University,Yantai, Shandong,China

Abstract:

Thyroid dysfunction is an important factor to cause failure in assisted reproduction technology (ART) procedures. In this study, we recorded the serum level of thyroid autoantibody to fig. out its relationship with the ART outcome. The results showed that the serum concentrations of TSH had a statistically significant increase between the basal level and the levels at time of serum pregnancy test both in women with and without thyroid autoantibody (p= 0.002 and p=0.019, respectively). Additionally, the TSH level increased significantly in thyroid autoantibody-positive group than those in thyroid autoantibody-negative group during controlled ovarian hyper stimulation (COH) process(p = 0.006). The risk of preterm delivery was lower in thyroid autoantibody-negative group. In sum, the present study provided evidence of an association between thyroid autoantibody and preterm delivery in euthyroid women.

Page(s): 15-19

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 34, Issue: 1, Year: 2021

Keywords:

Thyroid stimulating hormone TSH , technology , thyroid autoantibodies , controlled ovarian hyper stimulation , assisted reproductive

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