Analgesic activity of alkyl piperidine derivatives. | [Pakistan Journal of Pharmaceutical Sciences • 2016]

Author(s):

1. Sarwat Jahan: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Sciences and Technology,Karachi,Pakistan

2. Shamim Akhtar: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi,Karachi,Pakistan

3. Arfa Kamil: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Sciences and Technology,Karachi,Pakistan

4. Nousheen Mushtaq: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi,Karachi,Pakistan

5. Zafar Saied Saify: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi,Pakistan

6. Muhammad Arif: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi,Karachi,Pakistan

Abstract:

Piperidine is the most significant scaffold which reveals therapeutic potential because of its conformationally flexible nature. During the course of present investigations synthetic quaternary salts of alkyl piperidine with various phenacyl bromides were explored for their possible analgesic activity. Compounds I analogs (1a-1f) and compound II analogs (IIa-IIf) showed varying degree of analgesic activity when compared with pethidine as standard and its duration by tail immersion method.

Page(s): 77-82

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 29, Issue: 1, Year: 2016

Keywords:

Alkylpiperidinederivatives , analgesicactivity

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