Abstract:
Agricultural and domestic use of permethrin, a pyrethroid insecticide, has led to intoxication of varying intensities in non target organisms including human. In present study, teratogenicity and embryotoxicity of permethrin was tested in developing chick(Gallus domesticus). Different concentrations of permethrin (0, 5, 10 and 20ppm) were prepared in sterilized distilled water. These doses were injected into eggs on 3rd day while recovery of embryos was done on 7th day of incubation. Disrupted embryos with microcephly, hydrocephaly, short neck, micromelia, amelia, micrognathia, agnathia, cataract, ectopiacordis, omphalocoel, axis distortion, anencephaly, anophthalmia, microphthalmia, phocomelia with reduced body weight and crown- rump length in all dose groups were obtained. Adverse histological changes appeared in the form of disrupted and malformed visceral organs, vertebral bone and spina bifida as compared to control. The findings of this study clearly indicate that permethrin is potentially toxic to developing chicks, especially the highest concentrations used in the study.
Keywords:
Permethrin
,
embryotoxicity
,
Teratogenicity
,
Gallus domesticus