A sensor for determination of tramadol in pharmaceutical preparations and biological fluids based on multi-walled carbon nanotubes-modified glassy carbon electrode. | [Journal of Chemical Society of Pakistan • 2013]

Author(s):

1. Mohammad Afrasiabi: Young Researchers Club, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran

2. Zeinab Rezayati Zad: Department of Chemistry, University of Arak, Arak, Iran

3. Shokat Kianipour: Young Researchers Club, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran

4. Ali Babaei: Department of Chemistry, University of Arak, Arak, Iran; Research Center for Nanotechnology, University of Arak, Iran

5. Ali Reza Taheri: Department of Chemistry, University of Arak, Arak, Iran

Abstract:

A chemically modified electrode is constructed based on multi-walled carbon nanotube modified glassy carbon electrode (MWCNTs/GCE). It is demonstrated that this sensor could be used for determination of pharmaceutical important compound tramadol (TRA). The measurements were carried out using differential pulse voltammetry (DPV), cyclic voltammetry (CV) and chronoamperometry (CA) methods. DPV experiments of various concentration of TRA showed two linear dynamic ranges. The first linear dynamic range was from 4 µM to 35 µM, and the second linear dynamic range was between 60 µM to 550 µM. A detection limit of 0.38 µM (S/N = 3) was obtained. The analytical performance of this sensor has been evaluated for the detection of TRA in human serum, human urine and some pharmaceutical preparations with satisfactory results.

Page(s): 1106-1112

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 35, Issue: 4, Year: 2013

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