A study of biogenic amines in central aortic and coronary sinus blood in ischemic heart disease. | [Pakistan Heart Journal • 1993]

Author(s):

1. Naveen Chandra: Cardiology Department, King George's Medical College, Lucknow, India

2. Balram Bhargava: Cardiology Department, King George's Medical College, Lucknow, India

3. V. S. Narain: Cardiology Department, King George's Medical College, Lucknow, India

4. P. K. Nigam: Cardiology Department, King George's Medical College, Lucknow, India

5. V. K. Puri: Cardiology Department, King George's Medical College, Lucknow, India

6. M. Hasan: Cardiology Department, King George's Medical College, Lucknow, India

Abstract:

This article presents a study of aortic and coronary sinus epinephrine (E), nor-epinephrine (NE), dopamine (DA) and serotonin (5-HT) in fourteen patients with stable angina (SA), six patients with vasospastic angina (VA) and six control subjects (C). SA patients were studied at rest and during incremental atrial pacing. VA patients were studied at rest and during various stages of vasospasm. E and DA were same in SA, VA and C subjects and did not rise with pacing or during vasospasm. NE was also same in all three subgroups but increased during vasospasm (p) but not with atrial pacing. 5-HT was, however, higher in SA and VA patients as compared to C subjects (p) and increased further during vasospasm (p) but not with atrial pacing. This increase in NE and 5HT during vasospasm was seen before EKG changes manifested or angina occurred. Thus NE and 5-HT play an important causative role in vasospasm, and are not released as a secondary phenomenon in angina. Serotonin is elevated even during resting state in SA and VA. The role of E and DA could not be established.

Page(s): 26-29

DOI: DOI not available

Published: Journal: Pakistan Heart Journal, Volume: 26, Issue: 3--4, Year: 1993

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