Pakistan Science Abstracts
Article details & metrics
No Detail Found!!
Targeted Drug Delivery with Green Nanoparticles: A New Frontier in Toxoplasma gondii Infection Treatment
Author(s):
1. Meshal Alshamrani: Department of Pharmaceutics, Pharmacy College, Jazan University,,Saudi Arabia
Abstract:
Toxoplasmosis caused by the obligate intracellular parasite Toxoplasma gondii remains a notable health burden on animals and humans worldwide. Various chemical drugs have been utilized to treat T. gondii infections but are noted by low efficacy, high side effects, and high drug resistance. Such limitations necessitate the development of new therapeutic approaches to combat parasitic infections. Targeted drug delivery by nanoparticles (NPs), specifically by green synthesized NPs has been shown to be an effective technique for overcoming these limitations. Various NPs synthesized from different parts of plants, fungi, and bacteria offer better biodegradable, biocompatible, and environmentally friendly alternatives compared to traditional drug carriers. Such bioengineered NPs improve drug solubility, extended circulation time, and improve controlled release of drugs at the site of interest. In addition, they have a potential therapeutic effect because of their inherent physiochemical character with less toxicity. Their drug action can also be augmented through surface modification and functionalization, size and shape engineering, nano-carrier hybridization, gene silencing, and combination therapy. Targeted drug delivery using green synthesized NPs opens up a new avenue in T. gondii treatment towards the development of safer and more environmentally friendly therapeutic approaches.
Page(s): 84-95
Published: Journal: Pakistan Veterinary Journal, Volume: 45, Issue: 1, Year: 2025
Keywords:
Alternatives Conventional drugs Drug delivery Green nanoparticles Toxoplasma gondii
References:
[1] Abbas RZ,Ambrose S,Khan AMA .2025 .Nanoparticles as an alternative strategy to control foot and mouth disease virus in bovines. Biol Trace Elem Res, 203 : 1-17.
[2] El Hamid Abd,Desouky DK,AbdEllatif EM,S EM .2024 .Green synthesis and characterization of titanium dioxide nanoparticles by Aspergillus niger DS22 and its potential application in medical fields. Egypt J Bot, 64(2) : 629-653.
[3] Abdel-Wahab BA,Haque A,Alotaibi HF .2024 .Eco-friendly green synthesis of silver nanoparticles utilizing olive oil waste by-product and their incorporation into a chitosan-aloe vera gel composite for enhanced wound healing in acid burn injuries. Inorg Chem Commun, 165 : 112587.
[4] Abdellatif AAH,Mostafa MAH,Konno H .2024 .Exploring the green synthesis of silver nanoparticles using natural extracts and their potential for cancer treatment. 3 Biotech, 14 : 1-21.
[5] Adem D and Ame M .2023 .Toxoplasmosis and its significance in public health: a review. J Biomed Sci, 2 : 1-20.
[6] Ahamad N,Kar A,Mehta S .2021 .Immunomodulatory nanosystems for treating inflammatory diseases. Biomaterials, 274 : 120875.
[7] Al-Biatee ST .2024 .The zoonotic aspect of Toxoplasma gondii in human and animals:A review. Al-Anbar J Vet Sci, 17(2) : 2707.
[8] Alajmi RA,Al-Megrin WA,Metwally D .2019 .Anti-Toxoplasma activity of silver nanoparticles green synthesized with Phoenix dactylifera and Ziziphus spina-christi extracts which inhibits inflammation through liver regulation of cytokines in Balb/c mice. Biosci Rep, 39 : BSR20190379.
[9] Alanazi AD,Alnomasy SF .2023 .anti-inflammatory activities of green synthesized copper nanoparticles for treatment of chronic Toxoplasma gondii infection. Pharmaceuticals, 16 : 1574.
[10] Albalawi AE,Alanazi AD,Alyousif MS .2021 .The high potency of green synthesized copper nanoparticles to prevent the Toxoplasma gondii infection in mice. Acta Parasitol, 66 : 1472-1479.
[11] Aliero AS,Hasmoni SH,Haruna A .2025 .Bibliometric exploration of green synthesized silver nanoparticles for antibacterial activity. Emerg Contam, 11 : 100411.
[12] Almuhayawi MS,Alruhaili MH,Soliman MKY .2024 .Investigating the in vitro antibacterial, antibiofilm, antioxidant, anticancer and antiviral activities of zinc oxide nanoparticles biofabricated from Cassia javanica. PLoS One, 19 : e0310927.
[13] Alsaiari NS,Alzahrani FM,Amari A .2023 .Plant and microbial approaches as green methods for the synthesis of nanomaterials: synthesis, applications, and future perspectives. Molecules, 28 : 463.
[14] Alsharedeh RH,Rezigue M,Bashatwah RM .2024 .Nanomaterials as a potential target for infectious parasitic agents. Curr Drug Deliv, 21 : 828-851.
[15] Ambrose S,Khan AMA,Liaqat I .2025 .Targeted and efficient therapeutic effect of nanoparticles against malignant tumor: nanoparticles against tumor. Lett Anim Biol, 5 : 19-29.
[16] Anwar M,Muhammad F,Akhtar B .2021 .Biodegradable nanoparticles as drug delivery devices. J Drug Deliv Technol, 64 : 102638.
[17] Arafa FM,Mogahed NMFH,Eltarahony MM .2023 .Biogenic selenium nanoparticles: trace element with promising antiToxoplasma effect. Pathog Glob Health, 117 : 639-654.
[18] Arrighi F,Granese A,Chimenti P .2023 .Novel therapeutic opportunities for Toxoplasma gondii, Trichomonas vaginalis, and Giardia intestinalis infections. Expert Opin Ther Pat, 33 : 211-245.
[19] Arya S,Mahajan P,Mahajan S .2021 .influence of processing parameters to control morphology and optical properties of solgel synthesized ZnO nanoparticles. ECS J Solid State Sci Technol, 10 : 023002.
[20] Asghar T,Nawaz Y,Khan AMA .2024 .Immunomodulation of nanoparticles: Unveiling immunosuppressive and anti- inflammatory properties: Nanoparticles and immunomodulation. Lett Anim Biol, 4(2) : 28-39.
[21] Azadpour M,Farajollahi MM,Dariushnejad H .2021 .Effects of synthetic silymarin-PLGA nanoparticles on M2 polarization and inflammatory cytokines in LPS-treated murine peritoneal macrophages. Iran J Basic Med Sci, 24(10) : 1446-1454.
[22] Balkrishna A,Kumar A,Arya V .2021 .Phytoantioxidant functionalized nanoparticles: a green approach to combat nanoparticle‐induced oxidative stress. Oxid Med Cell Longev, 1 : 3155962.
[23] Banjara RA,Kumar A,Aneshwari R .2024 .A comparative analysis of chemical vs green synthesis of nanoparticles and their various applications. Environ Nanotechnol Monit Manag, 22 : 100988.
[24] Buragohain Barua N,AK Barua N .2024 .Therapeutic potential of silver nanoparticles (AgNPs) as an antimycobacterial agent: a comprehensive review. Antibiotics, 13 : 1106.
[25] Hajj RE,Tawk L,Itani S .2021 .Toxoplasmosis: Current and emerging parasite druggable targets. Microorganisms, 9 : 2531.
[26] Haldar T,Sardar SK,Ghosal A .2024 .Andrographolide induced cytotoxicity and cell cycle arrest in Giardia trophozoites. Exp Parasitol, 262 : 108773.
[27] Hamidzade M,Motlaghzadeh S,Khales P .2024 .Metal and metal oxide nanoparticles as agents against human infectious viruses. Curr Nanosci, 20 : 510-529.
[28] Hanafy NAN .2025 .Fundamentals and Biomedical Applications of Chitosan Nanoparticles. , : 267-308.
[29] Hematizadeh A,Ebrahimzadeh MA,Sarvi S .2023 .In vitro and in vivo anti-parasitic activity of Sambucus ebulus and Feijoa sellowiana extracts silver nanoparticles on Toxoplasma gondii Tachyzoites. Acta Parasitol, 68 : 557-565.
[30] Herdiana Y,Wathoni N,Shamsuddin S .2022 .Drug release study of the chitosan-based nanoparticles. Heliyon, 8 : e08674.
[31] Hu X,Zhu H,He X .2023 .The application of nanoparticles in immunotherapy for hepatocellular carcinoma. J Control Release, 355 : 85-108.
[32] Gupta SK,Mao Y .2021 .A review on molten salt synthesis of metal oxide nanomaterials: Status, opportunity, and challenge. Prog Mater Sci, 117 : 100734.
[33] Gubbels M-J,Keroack CD,Dangoudoubiyam S .2020 .Fussing about fission: Defining variety among mainstream and exotic apicomplexan cell division modes. Front Cell Infect Microbiol, 10 : 269.
[34] Green-Ross NT .2023 .Tannins effects on Toxoplasma gondii growth and its mechanism of Action. , : 1-12.
[35] Gissot M .2022 .Toxoplasma gondii:Asexual cycle in the intermediate host. In: Lifecycles of Pathogenic Protists in Humans, 35 : 391-417.
[36] Georgeous J,AlSawaftah N,Abuwatfa WH .2024 .Review of gold nanoparticles: synthesis, properties, shapes, cellular uptake, targeting, release mechanisms and applications in drug delivery and therapy. Pharmaceutics, 16 : 1332.
[37] García-López LL,Vargas-Montes M,Osorio-Méndez JF .2024 .T-cell exhaustion phenotype in human asymptomatic and ocular toxoplasmosis. Ocul Immunol Inflamm, 32 : 1218-1227.
[38] Gao X,Zhong Y,Liu Y .2021 .The role and function of regulatory T cells in Toxoplasma gondii‐induced adverse pregnancy outcomes. J Immunol Res, 8782672 : .
[39] Ferreira PTM,Oliveira-Scussel ACM,Sousa RAP .2023 .Macrophage migration inhibitory factor contributes to drive phenotypic and functional macrophages activation in response to Toxoplasma gondii infection. Immunobiology, 228 : 152357.
[40] Felicia WXL,Rovina K,Mamat H .2024 .Advancements in fruit preservation technologies: harnessing chitosan, aloe vera gel, and plant-based essential oils for coating applications. Appl Food Res, 4 : 100439.
[41] El-Sayyad GS,Elfadil D,Mosleh MA .2024 .Eco-friendly strategies for biological synthesis of green nanoparticles with promising applications. BioNanoSci, 14 : 3617-3659.
[42] El-Kady AM,Hassan S,Mohamed A,K A .2023 .Zinc oxide nanoparticles produced by Zingiber officinale ameliorates acute toxoplasmosis-induced pathological and biochemical alterations and reduced parasite burden in mice model. PLoS Negl Trop Dis, 17 : e0011447.
[43] Dubey JP .2021 .Outbreaks of clinical toxoplasmosis in humans: Five decades of personal experience, perspectives and lessons learned. Parasit Vectors, 14 : 263.
[44] Delgado ILS,Zúquete S,Santos D .2022 .The apicomplexan parasite Toxoplasma gondii. Encyclopedia, 2 : 189-211.
[45] De Santis S,Cavalcanti E,Mastronardi M .2015 .Nutritional keys for intestinal barrier modulation. Front Immunol, 6 : 612.
[46] Damasceno-Sá JC,de Souza FS,Dos Santos TAT .2021 .Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain. Mem Inst Oswaldo Cruz, 116 : e200417.
[47] da Silva Sanfelice RA,Silva TF,Tomiotto-Pellissier F .2022 .Biogenic silver nanoparticles reduce Toxoplasma gondii infection and proliferation in RAW 264.7 macrophages by inducing tumor necrosis factor-alpha and reactive oxygen species production in the cells. Microbes Infect, 24 : 104971.
[48] da Silva Sanfelice RA,da Silva Bortoleti BT,Tomiotto-Pellissier F .2021 .Biogenic silver nanoparticles (AgNp-Bio) reduce Toxoplasma gondii infection and proliferation in HeLa cells, and induce autophagy and death of tachyzoites by apoptosis-like mechanism. Acta Trop, 222 : 106070.
[49] Chu KB,Quan FS .2021 .Advances in Toxoplasma gondii vaccines: Current strategies and challenges for vaccine development. Vaccines, 9 : 413.
[50] Cheraghipour K,Khalaf AK,Moradpour K .2023 .antiparasitic effects of zinc oxide nanoparticles-eugenol nanosuspension against Toxoplasma gondii infection. Heliyon, 9 : 19295.
[51] Chen R,Peng JJ,Mohsin M .2022 .Construction and evaluation of the Toxoplasma gondii DNA vaccine targeting. DEC-205. Pak Vet J, 42(2) : 256-260.
[52] Chatterjee S,Lou XY,Liang F .2022 .Surface-functionalized gold and silver nanoparticles for colorimetric and fluorescent sensing of metal ions and biomolecules. Coord Chem Rev, 459 : 214461.
[53] Brito C,Lourenço C,Magalhães J .2023 .Nanoparticles as a delivery system of antigens for the development of an effective vaccine against Toxoplasma gondii. Vaccines, 11 : 733.
[54] Bhalani DV,Nutan B,Kumar A .2055 .Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines, 10 : .
[55] Behera US,Poddar S,Deshmukh MP .2024 .Comprehensive review on the role of nanoparticles and nanofluids in chemical enhanced oil recovery: interfacial phenomenon, compatibility, scalability, and economic viability. Energy Fuels, 38 : 13760-13795.
[56] Ihara F and Yamamoto M .2024 .The role of IFN-γ-mediated host immune responses in monitoring and the elimination of Toxoplasma gondii infection. Int Immunol, 36 : 199-210.
[57] İlgar M,Karakuş S,Kilislioğlu A .2022 .Design, characterization and evaluation of the drug-loaded chitosan/cerium oxide nanoparticles with pH-controlled drug release. Polym Bull, 79 : 6693-6708.
[58] Imdad MJ,Ahmed F,Zhao Y .2025 .Targeting bacterial spores with metallic nanoparticles: a promising alternative for food safety. Curr Opin Food Sci, 62 : 101273.
[59] İpek P,Baran MF,Baran A .2024 .Green synthesis and evaluation of antipathogenic, antioxidant, and anticholinesterase activities of gold nanoparticles (Au NPs) from Allium cepa L. peel aqueous extract. Biomass Convers Biorefin, 14 : 10661-10670.
[60] Iqbal Y,Ahmed I,Irfan MF .2023 .Recent advances in chitosan-based materials; The synthesis, modifications and biomedical applications. Carbohydr Polym, 321 : 121318.
[61] Jaikishan S,Lavainne M,Wiedmer SK .2024 .Nanoplasmonic sensing for studies on liposomes and extracellular vesicles. Sens Actuators Rep, 7 : 100192.
[62] Jeevanandam J,Kiew SF,Boakye-Ansah S .2022 .Green approaches for the synthesis of metal and metal oxide nanoparticles using microbial and plant extracts. Nanoscale, 14 : 2534-2571.
[63] Jeong G-J,Rather MA,Khan F .2024 .pH-responsive polymeric nanomaterials for the treatment of oral biofilm infections. Colloids Surf. B Biointerfaces, 234 : 113727.
[64] Joseph TM,Kar Mahapatra D,Esmaeili A .2023 .Taking a unique position in medicine. Nanomaterials, 13 : 574.
[65] Joudeh N and Linke D .2022 .Nanoparticle classification, physicochemical properties, characterization, and applications: A comprehensive review for biologists. J Nanobiotechnology, 20 : 262.
[66] Marques-Santos F,Faria RX,Reis Amendoeira MR .2024 .The search for drugs derived from natural products for Toxoplasma gondii infection treatment in the last 20 years. A systematic review. Curr Top Med Chem, 24 : 1960-1999.
[67] Kaiaty AM,Salib FA,El-Gameel SM .2023 .Emerging alternatives to traditional anthelmintics: the in vitro antiparasitic activity of silver and selenium nanoparticles, and pomegranate (Punica granatum) peel extract against Haemonchus contortus. Trop Anim Health Prod, 55 : 317.
[68] Karimi M,Homayoonfal M,Zahedifar M .2024 .Development of a novel nanoformulation based on aloe vera-derived carbon quantum dot and chromium-doped alumina nanoparticle (Al2O3: Cr@ Cdot NPs): Evaluating the anticancer and antimicrobial activities of nanoparticles in photodynamic therapy. Cancer Nanotechnol, 15 : 26.
[69] KarimiPourSaryazdi A,Tavakoli P,Barati M .2019 .Anti-Toxoplasma effects of silver nanoparticles based on ginger extract: an in vitro study. J Arch Mil Med, 7(4) : e104248.
[70] Kaur H,Kumar S,Bouzid G .2024 .Exploring the role of different phytochemicals on the morphological variations of metal and metal oxide nanomaterials for biomedical application. Interactions, 245 : 234.
[71] Khan SS,Kour D,Kaur T .2024 .Microbial nanotechnology for precision nanobiosynthesis: innovations, current opportunities and future perspectives for industrial sustainability. Curr Microbiol, 81 : 251.
[72] Krishna AG,Sahana S,Venkatesan H .2024 .Green synthesis of copper nanoparticles: a promising solution for drug resistance and cancer therapy challenges. J Egypt Natl Canc Inst, 36 : 44.
[73] Kumar A,Dutta S,Kim S .2022 .Solid-state reaction synthesis of nanoscale materials: strategies and applications. Chem Rev, 122 : 12748-12863.
[74] Li TT,Zhao DY,Liang QL .2023 .The antioxidant protein glutaredoxin 1 is essential for oxidative stress response and pathogenicity of Toxoplasma gondii. J Off Publ Fed Am Soc Exp Biol, 37 : e22932.
[75] Liu J,Cabral H,Mi P .2024 .Nanocarriers address intracellular barriers for efficient drug delivery, overcoming drug resistance, subcellular targeting and controlled release. Adv Drug Deliv Rev, 207 : 115239.
[76] Liu X,Lu B,Fu J .2021 .Amorphous silica nanoparticles induce inflammation via activation of NLRP3 inflammasome and HMGB1/TLR4/MYD88/NF-kb signaling pathway in HUVEC cells. J Hazard Mater, 404 : 124050.
[77] Machado LF,Sanfelice RA,Bosqui LR .2020 .Biogenic silver nanoparticles reduce adherence, infection, and proliferation of Toxoplasma gondii RH strain in HeLa cells without inflammatory mediators induction. Exp Parasitol, 211 : 107853.
[78] Mahmoud E-HM,Abdulsalam L,Moustafa E-H .2025 .AntiProtozoan Applications of the Biogenic Nanoparticles and Their Mechanism of Action, In: Expanding Nanobiotechnology: Applications and Commercialization. , : 241-284.
[79] Mahmoudzadeh S,Nozad Charoudeh H,Marques CS .2021 .The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review. Parasitol Res, 120 : 2303-2309.
[80] Majeed QAH,Alnomasy SF,Shater AF .2024 .High efficacy of green synthesized silver nanoparticles for treatment of Toxoplasma gondii infection through their immunomodulatory, anti-inflammatory, and antioxidant potency. Acta Parasitologica, 69 : 1201-1211.
[81] Manosalva N,Tortella G,Cristina Diez M .2019 .Green synthesis of silver nanoparticles: effect of synthesis reaction parameters on antimicrobial activity. World J Microbiol Biotechnol, 35 : 1-9.
[82] Nemati S,Mohammad Rahimi H,Hesari Z .2022 .Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its antiToxoplasma activity. BMC Complement Med Ther, 22 : 1-11.
[83] Mehnath S,Das AK,Verma SK .2021 .Biosynthesized/greensynthesized nanomaterials as potential vehicles for delivery of antibiotics/drugs, In: Comprehensive analytical chemistry. Vol, 94 : 363-432.
[84] Mohsin M,Aleem MT,Goraya MU .2024 .Natural products and pseudo-natural products against veterinary disease-causing microorganisms. Front Vet Sci, 11 : 1429587.
[85] Mondéjar-López M,García-Simarro MP,Navarro-Simarro P .2024 .A review on the encapsulation of “eco-friendly” compounds in natural polymer-based nanoparticles as next-generation nanoagrochemicals for sustainable agriculture and crop management. Int J Biol Macromol, 280 : 136030.
[86] Mottaghi M,Karami P,Hesari Z .2024 .Evaluation of anti-Toxoplasma effects of solid lipid nanoparticles carrying Cinnamon zeylanicum and Moringa oleifera oil extracts. BMC Complement Med Ther, 24 : 375.
[87] Mukherjee A,Sarkar D,Sasmal S .2021 .A review of green synthesis of metal nanoparticles using algae. Front Microbiol, 12 : 693899.
[88] Murugappan S,Pebam M,Sankaranarayanan SA .2024 .green synthesis of nanomaterials: biological and environmental applications. , : 131-168.
[89] Mustafa S,Abbas RZ,Saeed Z .2024 .Use of metallic nanoparticles against Eimeria-the coccidiosis-causing agents: A comprehensive review. Biol Trace Elem Res, 202 : 1-20.
[90] Naghib SM,Amiri S,Mozafari MR .2024 .Stimuli-responsive chitosan-based nanocarriers for drug delivery in wound dressing applications: A review. Carbohydr Polym Technol Appl, 7 : 100497.
[91] Negesa G andKebede IA .2024 .Review on toxoplasmosis and its status in Ethiopia. Mathews J Vet Sci, 8 : 1-12.
[92] Noah NM,Ndangili PM .2022 .Green synthesis of nanomaterials from sustainable materials for biosensors and drug delivery. Sensors Int, 3 : 1-15.
[93] Olajide JS,Cai J .2020 .Perils and promises of pathogenic protozoan extracellular vesicles. Front Cell Infect Microbiol, 10 : 1-17.
[94] Palomino-Cano C,Moreno E,Irache JM .2024 .Targeting and activation of macrophages in leishmaniasis. A focus on iron oxide nanoparticles. Fron Immunol, 15 : 1-21.
[95] Pare B,Joshi R,Solanki VS .2024 .Synthesis and characterisation of visible light-responsive Fe-doped BiOCl NPs and their application for the remediation of textile dye by LED irradiation. Int J Environ Anal, : 1-23.
[96] Pechyen C,Tangnorawich B,Toommee S .2024 .Green synthesis of metal nanoparticles, characterization, and biosensing applications. Sensors Int, 5 : 1-17.
[97] Peng Y,Yang Z,Sun H .2024 .Nanomaterials in medicine: understanding cellular uptake, localization, and retention for enhanced disease diagnosis and therapy. Aging Dis, 16 : 168-208.
[98] Prakash A,Praveen RP,Daisy PA .2020 .A Review on Nanoparticles. Int J Pharm Sci Rev Res, 64 : 64-68.
[99] Rana A,Yadav K,Jagadevan S .2020 .A comprehensive review on green synthesis of nature-inspired metal nanoparticles: Mechanism, application and toxicity. J Clean Prod, 272 : 1-25.
[100] Rasool A,Sri S,Zulfajri M .2024 .Nature inspired nanomaterials, advancements in green synthesis for biological sustainability. Inorg Chem Commun, 169 : 1-29.
[101] Rodriguez JB,Szajnman SH .2023 .An updated review of chemical compounds with anti-Toxoplasma gondii activity. Eur J Med Chem, 262 : 1-16.
[102] Rovira-Diaz E,El-Naccache DW,Reyes J .2022 .The impact of helminth coinfection on innate and adaptive immune resistance and disease tolerance during toxoplasmosis. J Immunol, 209 : 2160-2171.
[103] Sasai M and Yamamoto M .2019 .Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection. Exp Mol Med, : 1-10.
[104] Sasai M and Yamamoto M .2022 .Anti-Toxoplasma host defense systems and the parasitic counterdefense mechanisms. Parasitol Int, 89 : 1-9.
[105] Serdar G .2024 .Biosynthesis and characterization of gold nanoparticles using microwave-assisted technology from pomegranate (Punica granatum L.) leaf extract produced by the method of supercritical fluid extraction (SFE). Plasmonics, 19 : 2233-2243.
[106] Shaba EY,Tijani JO,JO JO .2021 .A critical review of synthesis parameters affecting the properties of zinc oxide nanoparticles and its application in wastewater treatment. Appl Water Sci, 11 : 1-41.
[107] Shah DD,Chorawala MR,Mansuri MKA .2024 .Biogenic metallic nanoparticles: from green synthesis to clinical translation. NaunynSchmiedeberg's Arch Pharmacol, 397 : 8603-8631.
[108] Yu Z,Lu Y,Cao W .2021 .Nano DNA vaccine encoding Toxoplasma gondii histone deacetylase SIR2 enhanced protective immunity in Mice. Pharmaceutics, 13(10) : 1582.
[109] Zakir M,Khurshid A,Rasheed MA .2024 .The green synthesis of biocompatible nanocomposites and its application for the ontarget delivery of the anticancer drugs. J Mater Res, 39 : 325-341.
[110] Zeb A,Gul M,Nguyen TTL .2022 .Controlled release and targeted drug delivery with poly (lactic-co-glycolic acid) nanoparticles: reviewing two decades of research. J Pharm Investig, 52 : 683-724.
[111] Zeleňáková A,Zeleňák V,Beňová E .2024 .The surface modification of the silica-coated magnetic nanoparticles and their application in molecular diagnostics of virus infection. Sci Rep, 14 : 1-20.
[112] Zhao J,Ling L,Zhu W .2023 .M1/M2 re-polarization of kaempferol biomimetic NPs in anti-inflammatory therapy of atherosclerosis. J Controlled Release, 353 : 1068-1083.
[113] Zheng Y,Sun J,Luo Z .2024 .Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications. Cell Death Dis, 15 : 1-19.
[114] Zhi X,Yang P,Xu Y .2023 .Toll-like receptor-targeted nanoparticles: A powerful combination for tumor immunotherapy. Nano Today, 53 : 1-26.
[115] Shammaa AM,Powell TG,Benmerzouga I .2021 .Adverse outcomes associated with the treatment of Toxoplasma infections. Sci Rep, 11 : 1-8.
[116] Rukh L,Ullah S,Naqvi MAQ .2024 .Cytotoxicity and genotoxicity induced by metal-based nanoparticles in humans and animals: nanoparticle toxicity. Lett Anim Biol, 4(2) : 01-10.
[117] Saadatmand M,Al-Awsi GRL,Alanazi AD .2021 .Green synthesis of zinc nanoparticles using Lavandula angustifolia Vera. Extract by microwave method and its prophylactic effects on Toxoplasma gondii infection. Saudi J Biol Sci, 28 : 6454-6460.
[118] Sahin H,Yucel O,Holloway P .2024 .Comparison of drug delivery systems with different types of nanoparticles in terms of cellular uptake and responses in human endothelial cells, pericytes, and astrocytes. Pharmaceuticals, 17 : 1-25.
[119] Sana M,Rashid M,Rashid I .2022 .Immune response against toxoplasmosis-some recent updates RH: Toxoplasma gondii immune response. Int J immunopathol Pharmacol, 36 : 1-18.
[120] Sharma L,Siedlewicz G,Pazdro K .2021 .The toxic effects of antibiotics on freshwater and marine photosynthetic microorganisms: State of the art. Plants, 10 : 1-15.
[121] Sheta MH,Abd El-Wahed AHM,Elshaer MA .2024 .Green synthesis of zinc and iron nanoparticles using Psidium guajava leaf extract stimulates cowpea growth, yield, and tolerance to saline water irrigation. Horticulturae, 10 : 1-20.
[122] Shim G .2024 .Precise subcellular targeting approaches for organelle-related disorders. Adv Drug Deliv Rev, 115411 : .
[123] Shiraz M,Imtiaz H,Azam A .2024 .Phytogenic nanoparticles: synthesis, characterization, and their roles in physiology and biochemistry of plants. Biometals, 37 : 23-70.
[124] Singh AK .2022 .A review on plant extract-based route for synthesis of cobalt nanoparticles: Photocatalytic, electrochemical sensing and antibacterial applications. Curr Res Green Sustain Chem, 5 : 1-9.
[125] Smith D,Lunghi M,Olafsson EB .2022 .A high-throughput amenable dual luciferase system for measuring Toxoplasma gondii bradyzoite viability after drug treatment. Anal Chem, 95 : 668-676.
[126] Soni V,Raizada P,Singh P .2021 .Sustainable and green trends in using plant extracts for the synthesis of biogenic metal nanoparticles toward environmental and pharmaceutical advances: A review. Environ Res, 202 : 1-18.
[127] Sudhimon S,Kumar MM,Yamini S .2024 .Bio prospecting of Aloe barbadensis miller (Aloe vera) for silver nanoparticles against breast cancer:A review. J King Saud Univer Sci, 36 : 1-10.
[128] Latha Thomas D,MS Thomas D .2023 .Alginate based nanocarriers for controlled drug delivery applications. In: Alginate Biomaterial: Drug Delivery Strategies and Biomedical Engineering, : 61-83.
[129] Xu J,Huang Y,Zhu S .2021 .A review of the green synthesis of ZnO nanoparticles using plant extracts and their prospects for application in antibacterial textiles. J Eng Fiber Fabr, 16 : 1-14.
[130] Yang Y,Cai C,Guo Y .2024 .Applications and perspectives of hydrogels in veterinary medicine. Pak Vet J, 44(4) : 998-1005.
[131] Yu Z,Cao W,Gao X .2021 .With chitosan and PLGA as the delivery vehicle, Toxoplasma gondii oxidoreductase-based DNA vaccines decrease parasite burdens in mice. Front Immunol, 12 : 726615.
[132] Yu Z,He K,Cao W .2022 .Nano vaccines for T. gondii ribosomal P2 protein with nanomaterials as a promising DNA vaccine against toxoplasmosis. Front Immunol, 13 : 839489.
[133] Tijani NA,Hokello J,Awojobi KO .2024 .Recent advances in Mushroom-mediated nanoparticles: A critical review of mushroom biology, nanoparticles synthesis, types, characteristics and applications. J Drug Deliv Sci Technol, 96 : 1-19.
[134] Tong WH,Pavey C,O'Handley R .2021 .Behavioral biology of Toxoplasma gondii infection. Parasit Vectors, 14 : 1-6.
[135] Ulusoy U .2023 .A review of particle shape effects on material properties for various engineering applications: from macro to nanoscale. Minerals, 13 : 1-81.
[136] Vijayaraghavan K and Ashokkumar T .2017 .Plant-mediated biosynthesis of metallic nanoparticles: A review of literature, factors affecting synthesis, characterization techniques and applications. J Environ Chem Engin, 5 : 4866-4883.
[137] Wakid MH,Alsulami MN,Farid M .2023 .Potential antitoxoplasmosis efficiency of Phoenix dactylifera extracts loaded on selenium nanoparticles. Infect Drug Resist, 16 : 7743-7758.
[138] Wani IA,Ahmad T,Khosla A .2021 .Recent advances in anticancer and antimicrobial activity of silver nanoparticles synthesized using phytochemicals and organic polymers. Nanotechnology, 32 : 462001.
Citations
Citations are not available for this document.
0

Citations

0

Downloads

1

Views