Altered liver morphology after sub-acute, sub-chronic and chronic oral administration of neem oil in albino rats. | [International Journal of Biology and Biotechnology • 2014]

Author(s):

1. Zahid Ali Kaimkhani: Baqai Medical University, Karachi, Pakistan

2. Syed Naeemul Hassan Naqvi: Department of Comparative Anatomy and Pharmacology, Baqai Institute of Pharmaceutical Sciences, Karachi, Pakistan

3. Masood Ahmed Shaikh: Department of Anatomy and Histology, Qassim University, KSA

4. Naushin Malik: Baqai Institute of Pharmaceutical Sciences, Karachi, Pakistan

5. Mohammad Rashid: Department of Anatomy, Baqai Medical University, Karachi, Pakistan

Abstract:

This research was undertaken to observe the subacute, subchronic and chronic effects of Neem oil on liver morphology and function after oral administration. Ninety six albino rats were used in this study with an equal ratio of male and females. The animals were administered with three different doses of neem oil orally daily for a period of three, six, twelve and twenty four weeks. The animals were divided in 4 different groups and each group was further divided into 4 subgroups on the basis of duration. Animals were sacrificed at the end of the experimental period. The liver was observed for gross and microscopic findings and the serum levels of liver enzymes, cholesterol and total proteins were studied Mild liver injuries were recorded in animals treated for 12 and 24 weeks. Biochemical parameters were unaffected except total serum protein levels in animals treated for 12 and 24 weeks. HPLC has demonstrated the presence of low concentration of neem compounds in serum indicating a bio-degradation and tissue utilization. This study has shown a dose and duration dependent mild toxic effects of neem oil on liver

Page(s): 459-470

DOI: DOI not available

Published: Journal: International Journal of Biology and Biotechnology, Volume: 11, Issue: 4, Year: 2014

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