1,3-disubstituted ureas as antiglycating agents. | [Journal of Chemical Society of Pakistan • 2013]

Author(s):

1. Shahnaz Perveen: Pakistan Council of Scientific & Industrial Research (PCSIR) Laboratories Complex, Peshawar, Pakistan

2. Sana Mustafa: Department of Chemistry, University of Karachi, Karachi, Pakistan

3. Khalid Mohammed Khan: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

4. Muhammad Iqbal Choudhary: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan

Abstract:

Twenty one (21) 1,3-disubstituted urea derivatives were screened for their antiglycating potential and some of them displayed promising activity. Compound N-butyl-N’-(4-nitrophenyl)urea (6) and N- isopropyl-N’-(4-nitrophenyl)urea (18) exhibited excellent activity and could be investigated in search of medicines treating diabetes and associated complications.

Page(s): 1605-1613

DOI: DOI not available

Published: Journal: Journal of Chemical Society of Pakistan, Volume: 35, Issue: 6, Year: 2013

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