Variations and Clinical Implications of Serum Gal-3 and IL-6 in Heart Failure Individuals Complicated with Renal Impairment | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2025]

Author(s):

1. Jianlong Li: Department of Cardiology, The Affiliated Hospital of Hebei University,Baoding, Hebei,China

2. Haiming Li: Department of Cardiology, The Affiliated Hospital of Hebei University,Baoding, Hebei,China

3. Yichao Zhang: Department of Cardiology, The Affiliated Hospital of Hebei University,Baoding, Hebei,China

4. Xing Fan: Department of Nephrology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, Hebei, China

5. Qian Wang: Department of Nephrology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, Hebei, China

6. Zhe Li: Department of Nephrology, The Affiliated Hospital of Hebei University, Baoding, Hebei, China; Key Laboratory of Bone Metabolism and Physiology in Chronic Kidney Disease of Hebei Province, Baoding, Hebei, China

Abstract:

Objective: To investigate the variations and clinical implications of serum Gal-3 and IL-6 values in individuals with heart failure (HF) complicated with renal impairment. Study Design: Analytical study. Place and Duration of the Study: Department of Nephrology, The A liated Hospital of Hebei University, Baoding, Hebei, China, from May 2022 to 2023. Methodology: A total of 80 HF individuals who were treated in the Department of Nephrology, The A liated Hospital of Hebei University, Baoding, Hebei, China, from May 2022 to 2023, were classi ed into the normal renal function band (n = 40) and the renal impairment band (n = 40) according to glomerular ltration rate (eGFR). The serum galactose-3 (Gal-3) and interleukin-6 (IL-6) values and their correlation with renal impairment were compared between the two bands, along with an analysis of the sensitivity and speci city of Gal-3 and IL-6 using receiver operating characteristic (ROC) curves. Results: There were higher Gal-3 and IL-6 values in the renal impairment band, in contrast to the normal renal function band (p <0.05). Spearman s correlation analysis indicated a signi cant association between Gal-3 and IL-6 values in HF individuals and renal impairment (p <0.05). The AUC values of Gal-3 and IL-6 in predicting renal impairment in HF individuals were <0.914 and <0.717, respectively; the speci city of Gal-3 and IL-6 in predicting renal impairment was 70.00% and 62.50%, respectively, the sensitivity was 97.50% and 80.00%, respectively. Conclusion: HF individuals complicated with renal impairment have increased serum Gal-3 and IL-6 values, both of which are signi cantly associated with renal impairment.

Page(s): 297-301

DOI: 10.29271/jcpsp.2025.03.297

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 35, Issue: 3, Year: 2025

Keywords:

Heart failure , Renal impairment , Interleukin6 protein , Galactose lectin3

References:

[1] Zaborska B,Frac MS,Smarz K,Paszkiet EP,Budaj A,Sitkiewicz D .2023 .The role of Galectin-3 in heart failure-The diagnostic, prognostic and therapeutic potential-where do we stand?. Int J Mol Sci, 10(17) : 13111.

[2] Iacoviello M,Di Serio F,Rizzo C,Leone M,Grande D,Guida P .2019 .Association between high Gal-3 serum levels and worsening of renal function in chronic heart failure outpatients. Biomark Med, 13(9) : 707-13.

[3] . .. , : .

[4] Kotby AA,Youssef OI,Elmaraghy MO .2017 .Galectin-3 in children with chronic heart failure with normal and reduced ejection fraction: Relationship to disease severity. Pediatr Cardiol, 10(1) : 95-102.

[5] . .Chinese society of cardiology of Chinese medical association; editorial board of Chinese Journal of Cardiology. [Guidelines for the diagnosis and management of chronic heart failure]. Zhonghua Xin Xue Guan Bing Za, 35(12) : 1076-95.

[6] Savarese G,Becher PM,Lund LH,Seferovic P,Rosano GMC,Coats AJS .2023 .Global burden of heart failure: A comprehensive and updated review of epidemiology. Cardiovasc Res, 10(17) : 3272-87.

[7] Han R,Li K,Li L,Zhang L,Zheng H .2019 .Expression of microRNA-214 and galectin-3 in peripheral blood of patients with chronic heart failure and its clinical signi canceE. xp Ther Med, 8318(2) : 1322-8.

[8] Costanzo MR .2019 .The cardiorenal syndrome in heart failure. Heart Fail Clin, 08(1) : 81-97.

[9] Luo BJ,Kong MH. .2019 .Clinical value of plasma growth di erentiation factor15, galectin3 and copeptin in diagnosis of cardiorenal syndrome. Hebei Med J, 08(8) : 7386-6.

[10] Plonka J,Olejnik A,Klus A,Dryja EG,Wylegala NW,Rzepiela L .2022 .Protective role of protein Klotho biomarker in acute heart failure. Euro Heart J Acute Cardio Care, 10 : 157.

[11] Watanabe S,Lei M,Nakagawa E,Takeshita E,Inamori KI,Shishido F .2023 .Neurological insights on two siblings with GM3 synthase de ciency due to novel compound heterozygous ST3GAL5 variants. Brain Dev, 01(5) : 270-7.

[12] Gaborit FS,Bosselmann H,Kistorp C,Iversen K,Kumler T .2016 .Galectin 3: Association to neurohumoral activity, echocardiographic parameters and renal function in outpatients with heart failure. BMC Cardiovasc Disord, 10 : 117.

[13] Bailon MM,Babkwoski MC .2020 .Monitoring renal damage in acute heart failure. Do we need a more global and comprehensive approach?. Rev Clin Esp, 02(9) : 576-7.

[14] Brankovic M,Akkerhuis KM,Hoorn EJ,van Boven N,van den Berge JC,Constantinescu A .2020 .Renal tubular damage and worsening renal function in chronic heart failure: Clinical determinants and relation to prognosis (Bio-SHiFT study. Clin Cardiol, 10(6) : 630-8.

[15] Verbrugge FH,Guazzi M,Testani JM,Borlaug BA JM .2020 .Altered hemodynamics and end-organ damage in heart failure: Impact on the lung and kidneyC. irculation, 10(10) : 998-1012.

[16] Tian F,Chen LP,Yuan G,Zhang AM,Jiang Y,LI S Y .2020 .Di erences of TNF-±, IL-6 and Gal-3 in lobar pneumonia and bronchial pneumonia caused by mycoplasma pneumoniae. Technol Health Care, 10(6) : 711-9.

[17] Z. .2019 .Changes in expression of serum chemokine CXCL13 and IL-6 after hip replacement, and the relationship with lower limb vein thrombus. Exp Ther Med, 8365(3) : 2113-8.

[18] Zhang Q,Dong G,Wang F,Ding W.,VEGF W. .2020 .and TSGF levels and prognosis in patients with osteosarcoma before and after treatment. J Cancer Res Ther, 11(2) : 20-42.

[19] Baccouche BM,Mahmoud MA,Nief C,Patel K,Horowitz BN .2023 .Galectin-3 is associated with heart failure incidence: A Meta-Analysis. Curr Cardiol Rev, 10(3) : e17112.

[20] Perez PC,Gonzalez-Juanatey JR,Nuche J,Blanco LM,Serrano I,Selles MM .2022 .Renal function impact in the prognostic value of Galectin-3 in acute heart failure. Front Cardiovasc Med, 861651 : 861651.

[21] Liu GW,Zeng JE,Li LF .2022 .Correlation analysis of serum IGF-1 and IL-6 and urinary albumin/creatinine ratio in patients with type 2 diabetic kidney disease. Front Endocrinol (Lausanne), 1082492 : 1082492.

[22] Yin C,Cheng C,Wang J,Zhang L,Purrunsing Y,Yang G .2020 .The relationship between urinary kidney injury molecule-1 and blood bone metabolism markers in patients with chronic kidney disease. Clin Nephrol, 10(2) : 65-76.

[23] He L,Qing F,Li M,Lan D M .2021 .Gal-3 in patients with thyroid cancer. Gland Surg, 10(3) : 1085-92.

Citations

Downloads

Views