An Estimate of Protective Immunity against SARS-CoV2: Comparison of Diferent Vaccine Types | [Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences • 2023]

Author(s):

1. Waseem Iqbal: Department of Pathology, Mardan Medical Complex Teaching Hospital, Mardan, Pakistan; Department of Medical Lab Technology, The University of Haripur, Haripur, Pakistan

2. Ikram Ullah: Department of Medical Lab Technology, The University of Haripur,Haripur,Pakistan

3. Uroosa Irum: Department of Microbiology, Abdul Wali Khan University Mardan,,Pakistan

4. Saima Siddiqi: Department of Rare and Infectious Disease, Institute of Biomedical and Genetic Engineering, Islamabad, Pakistan

5. Khalid Mahmood Khan: University of Agriculture,Faisalabad,Pakistan

Abstract:

Several types of vaccines have been approved to prevent SARS-CoV-2 infection. Few studies are conducted on the eficacy of COVID-19 vaccines. Vaccination is important to eliminate and fight SARS-CoV-2 infection and several vaccines have been approved. This study aimed to assess the incidence density of COVID-19 infection among the community, estimate the efectiveness of diferent types of vaccines (inactivated virus, viral vector or mRNA) and eficiency of incomplete and complete vaccination. In this observational cross-sectional study, a total of 4924 specimens were received from 1st January 2022 to 2nd February 2022 for the detection of SARS-CoV-2. The patient's age, gender, and vaccination data were recorded and S, N, and ORF 1ab genes were amplified after RNA extraction through PCR. out of which 1034 (20.99 %) cases were positive. Among 1034 (20.99 %) positive cases, 418 and 616 patients were vaccinated and non-vaccinated respectively. The cases of SARS-CoV-2 in vaccinated patients were categorized into a sudden infection (= 10 days) and late infection (=10 days) after the incomplete and complete dose of vaccination. Vaccination provides partial protection against SARS-CoV-2 infection. This might be due to the low eficacy and inability to detect recent variations in the protein structure of the virus.

Page(s): 377-382

DOI: 10.53560/PPASB(60-3)749

Published: Journal: Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, Volume: 60, Issue: 3, Year: 2023

Keywords:

SARSCoV2 , Ct Value , COVID19 Vaccine Types , Vaccine Efectiveness

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