Technehum-99m methylene diphosphonate scintimammography for evaluation of palpable breast masses | [Journal of College of Physicians and Surgeons--Pakistan : JCPSP • 2002]

Author(s):

1. ShoabShah: Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan.

2. Mah Muneer Khan: Khyber Teaching Hospital, Peshawar; Pakistan. “

3. Amjad Aziz Khan: Multan Institute of Nuclear Medicine Radiotherapy (MINAR), Multan, Pakistan.

4. AakifUllah Khan: Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan

5. Sher Mohammad Khan: Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar, Pakistan

Abstract:

To evaluate technetium-99m methylene diphosphonate (99mTc-MDP) as a noninvasive tumor-localizing agent in patients with palpable breast masses and to differentiate malignant from benign breast lesions. Design : It was an observational and experimental study. Place and Duration of Study: The study was conducted at the Institute of Radiotherapy and Nuclear Medicine (IRNUM), Peshawar during a six-month period (June to November, 1995). Subjects and Methods: 99mTc-MDP scintimammography (SMM) was performed in thirty patients with palpable breast masses (Group A). Ten patients with no palpable breast abnormality (Group B) also underwent "mTc-MDP breast study; they served as controls. Upright anterior, lateral and oblique lateral images of the breasts were acquired 10-30 minutes after intravenous injection of 740 MBq of 99mTc-MDR This was performed during routine bone scanning. SMM was followed by surgical and/or needle biopsy. Results: Breast cancer was histologically diagnosed in twenty-two (73%), and benign disease found in eight patients (27%). Of the twenty-two breast carcinomas, twenty (91 %) were detected using "mTc-MDP SMM, while no uptake was seen in two (9%). Of the eight patients with pathologically proven benign breast lesions, seven (88%) either did not show any uptake or showed faint bilateral accumulation. Focal 99mTc-MDP uptake was observed in one fibroadenoma. Conclusion: The study showed that SMM with "mTc-MDP is positive in a high percentage of patients with carcinoma of the breast and may differentiate malignant from benign masses

Page(s): 23-27

DOI: DOI not available

Published: Journal: Journal of College of Physicians and Surgeons--Pakistan : JCPSP, Volume: 12, Issue: 1, Year: 2002

Keywords:

biological , Tumor markers , Breast neoplasm , Technitium To 99m Medronate

References:

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