The role of single-cell RNA sequencing in cardiac tumour - a case report | [Journal of Pakistan Medical Association • 2023]

Author(s):

1. Xian-Jie Qi: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

2. Ting Wei: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

3. Isah Amir Abba: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

4. Sheng-Qiang Zhang: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

5. Jin-jin Meng: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

6. Chao Shi: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

7. Yiyao Jiang: Department of Cardiovascular Surgery, The First Affiliated Hospital of Bengbu Medical College,Bengbu,China

Abstract:

A 65-year-old woman presented to our hospital with 5 days of chest tightness, dyspnoea, and lower abdominal distension. Echocardiography revealed a mass in the right atrium. An emergency operation was carried out to prevent tumour shedding. The patient was discharged on the 4th day of tumour resection, without any complications At the 18 months follow-up, she suffered from kidney and lung tumours. She refused any treatment and passed away. scRNA-seq was applied to analyse the nature of the tumour. The cellular components of benign tumours include chondrocytes, smooth muscle cells, fibroblasts, mesenchymal stromal cells, and osteoblasts. Additionally, the cyclic guanosine monophosphate (cGMP-PKG) signalling pathway, transcriptional misregulation in cancer, and the p53 signalling pathway may be related to the growth of this tumour. scRNA-seq is a good approach to analyse growth patterns of cardiac tumours and helpful for distinguishing the nature of the tumour.

Page(s): 2462-2464

DOI: 10.47391/JPMA.7776

Published: Journal: Journal of Pakistan Medical Association, Volume: 73, Issue: 12, Year: 2023

Keywords:

sequence analysis , Cardiac tumour

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