The effect of Persian shallot (Allium hirtifolium Boiss.) extract on blood sugar and serum levels of some hormones in diabetic rats. | [Pakistan Journal of Pharmaceutical Sciences • 2013]

Author(s):

1. Mahmoodi Mehdi: Molecular Medicine Research Centre, and Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

2. Hosseini Javad: Molecular Medicine Research Centre, and Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

3. Seyed Mostafa Hosseini Zijoud: Department of Biochemistry, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

4. Mirzaee Mohammadreza: Molecular Medicine Research Centre, and Department of Biochemistry, Faculty of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

5. Mirzajani Ebrahim: Department of Biochemistry, Faculty of Medicine, Rasht University of Medical Sciences, Rasht, Iran

Abstract:

Diabetes mellitus (DM) is caused by hyperglycemia, resulting from defective insulin secretion or function. It is widely believed that the antioxidant micronutrients obtained from plants afford significant protection against diseases like diabetes mellitus. Present study was aimed to examine the effects of Persian shallot (Allium hirtifolium Boiss) on FBS, HbA1c, insulin, Triiodothyronine (T3) and Thyroxine (T4) levels in type 1 diabetic rats. Thirty two male Wistar rats were divided into 4 groups of 8. The diabetic groups received 100 and 200 mg/kg Persian shallot extract, diabetic control and normal control received %0.9 saline for 30 days. At the end of treatments, fasting blood specimens were collected. The levels of FBS, HbA1c, insulin, T3 and T4 were measured. Our findings indicated that hydroalcoholic extract of Persian shallot significantly decreased serum levels of FBS and HbA1c in treated groups (in a dose dependent manner) (P

Page(s): 397-402

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 26, Issue: 2, Year: 2013

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