Abstract:
Objective: Among the most prevalent malignant tumours globally, liver cancer has a high fatality rate. The incidence rate has risen steadily in recent years. Tumors cannot be removed by the immune system because immunological checkpoint genes are expressed in tumour cells. Basement membranerelated genes are the genes closely related to human diseases obtained by the latest research. Methods: First, immune checkpoint genes were used to extract genes associated to the basement membrane, and a prognostic model of immune checkpoint genes connected to the basement membrane was created. Survival analysis, progression-free survival analysis, and independent prognostic analysis were used to generate the C-index curves and ROC. The clinical grouping model's accuracy was verified using curves, principal component analysis, and validation. To further investigate the model's potential use, enrichment analysis, immunological analysis, and tumour mutation burden survival analysis were carried out. Finally, discussion of prospective medication targeting models follows. Results: A prognostic model was developed, and its accuracy in predicting patients' survival times from liver cancer was confirmed. The distinct functions and pathways of differential genes were discovered by GO and KEGG enrichment analysis. Four immune functions differentially expressed were found. The most altered genes in both the risk groups were analyzed. The research examined at 25 different drugs, with considerable differences in drug sensitivity across high- and low-risk groups. Conclusion: It offers new insights and methodologies for the survival prediction of liver cancer patients as well as the development of immune-tailored therapies by examining the relationship between immune checkpoint gene-associated basement membrane genes and the prognosis and immunity of liver cancer patients.
Page(s):
123-131
DOI:
DOI not available
Published:
Journal: Annals of Abbasi Shaheed Hospital & Karachi Medical & Dental College, Volume: 27, Issue: 3, Year: 2022
Keywords:
immunity
,
Liver Cancer
,
basement membrane
,
immune checkpoint gene