Three ultrasound guided plane blocks for perioperative analgesia in patients undergoing radical cystectomy: a randomized clinical trial | [Anaesthesia, Pain and Intensive Care • 2024]

Author(s):

1. Nazmy Edward Seif: Department of Anesthesia & Intensive Care, Faculty of Medicine, Cairo University, Cairo, Egypt

2. Manar Mahmoud El-Kholy: Department of Anesthesia & Intensive Care, Faculty of Medicine, Cairo University, Cairo, Egypt

3. Ashgan Raouf Ali: Department of Anesthesia & Intensive Care, Faculty of Medicine, Cairo University, Cairo, Egypt

4. Moustafa Mohamed Zalat: Department of Anesthesia & Intensive Care, Faculty of Medicine, Cairo University, Cairo, Egypt

5. Mohamed Elshazly: Department of Anesthesia & Intensive Care, Faculty of Medicine, Cairo University, Cairo, Egypt

Abstract:

Background &objective: Transmuscular quadratus lumborum plane block (QLPB), paravertebral plane block (PVPB), and erector spinae plane block (ESPB) are three regional anesthesia techniques for management of perioperative pain for surgical procedures on the trunk, including thorax and abdomen. We compared the effectiveness of PVPB, QLPB type III (QL3), and ESPB for perioperative analgesia during radical cystectomy performed for bladder cancer. Methodology: This randomized double-blind trial was performed on 120 patients, aged above 18 years, undergoing radical cystectomy under general anesthesia. Individuals were randomly divided into 3 equal groups: ESPB, PVPB, and QLPB. Blocks were performed under ultrasound guidance preoperatively on each side with 30 ml of 0.25% bupivacaine. Time to perform block and time to the first dose of morphine postoperatively, were noted. Intraoperative hemodynamic data, including MAP and heart rate (HR) were noted every 10 min for an hour, and then at 30 min intervals. Postoperatively, MAP and HR were recorded at 0, 2, 6, 12 and 24 hours. The connection between qualitative factors was investigated using the chi-square test and Fisher's exact test. For the purpose of comparing the groups, one-way ANOVA and the Bonferroni correction were used. A two-tailed P value < 0.05 was considered significant. Results: Time to perform block was substantially reduced in ESPB and QL3 groups compared to PVPB group. Time to the first dose of morphine was substantially delayed in the PVPB group than ESPB and QL3 groups. Total 24 h morphine consumption was substantially lower in the PVPB group than ESPB and QL3 groups. Postoperative visual analog scale measurements were substantially lower at 15 min, 30 min, and 12 h in the PVPB group than ESPB and QL3 groups and at 6 h in the ESPB and QL3 groups than in PVPB group. Postoperative mean arterial blood pressure and heart rate measurements were substantially reduced at 0 and 12 h in the PVPB group than in ESPB and QL3 groups and at 6 h in the ESPB and QL3 groups than in PVPB group. Conclusions: The ultrasound guided paravertebral plane block was superior to quadratus lumborum plane block type III and erector spinae plane block in providing more effective analgesia but with higher time to perform block.

Page(s): 84-91

DOI: 10.35975/apic.v28i1.2381

Published: Journal: Anaesthesia, Pain and Intensive Care, Volume: 28, Issue: 1, Year: 2024

Keywords:

Ultrasound , Radical cystectomy , Erector spinae plane block , Quadratus Lumborum Plane Block , Paravertebral Plane Block

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