Pakistan Science Abstracts
Article details & metrics
No Detail Found!!
The Protective effect of Olive Oil on Arsenic Induced Histological Changes in the Liver of Albino Rats.
Author(s):
1. Hira Waqas Cheema: Department of Anatomy, Islamic International Medical College, Riphah International University, Islamabad, Pakistan
2. Shabana Ali: Department of Anatomy, Islamic International Medical College, Riphah International University, Islamabad, Pakistan
Abstract:
Objective: To study the protective effect of olive oil against histological changes induced by arsenic in liver of albino rats. Study Design: Randomized control trail. Place and Duration of Study: The research was carried out from 1st to 30th November 2017 at National institute of Health, Islamabad. Materials and Methods: Forty five male adult albino rats were placed in three cages having 15 rats each. Distilled water was given to rats of control group I for 30 days. The rats of group II were given 40mg per kg per day of Sodium Arsenite dissolved in drinking water for 30 days. Rats in group III, in addition to sodium Arsenite received olive oil, 0.2ml per day for 30 days along with Sodium Arsenite. Dissection was done after 30 days and liver was dissected out for histological changes. Results: The use of olive oil improved the gross and microscopic changes induced by Arsenic in liver lobes(right lateral and left lateral) of Albino rats of group III as compared to group II rats, which received only arsenic. Among microscopic parameters, sinusoidal dilation, pyknosis and necrosis was markedly reduced by use of olive oil in group III rats whereas hemorrhage was absent in group III. Conclusion: Olive oil protects histological changes caused by arsenic in liver of Albino rats which include sinusoidal dilation, congestion, pyknosis, necrosis and haemorrhage.
Page(s): 200-205
DOI: DOI not available
Published: Journal: Journal of Islamic International Medical College, Volume: 13, Issue: 4, Year: 2018
Keywords:
Keywords are not available for this article.
References:
[1] García-ChávezE,SantamaríaA,Díaz-BarrigaF,MandevilleP,JuárezBI,Jiménez-CapdevilleME, 2003.Arsenite-induced formation of hydroxyl radical in the striatum of awake rats,Brain Res 976 82 -9
[2] SahaJC,DikshitAK,BandyopadhyayM,Saha KC, 1999.A Review of Arsenic Poisoning and its Effects on Human Health,Crit Rev Environ Sci Technol 29 281 -313
[3] IwamaK,NakajoS,AiuchiT,NakayaK., 2001.Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+- dependent production of superoxide,Int J Cancer 92 518 -26
[4] NandiD,PatraRC,SwarupD, 2005.Effect of cysteine, methionine, ascorbic acid and thiamine on arsenic-induced oxidative stress and biochemical alterations in rats,Toxicology 211 26 -35
[5] RatnaikeRN, 2003.Acute and chronic arsenic toxicity,Postgrad Med 79 391 -6
[6] JhalaDD,ChinoyNJ,RaoM V., 2008.Mitigating effects of some antidotes on fluoride and arsenic induced free radical t o x i c i t y i n m i c e o v a r y. F o o d C h e m To x i c o l, 46 1138 -42
[7] DukerAA,CarranzaEJM,HaleM., 2004.Arsenic geochemistry and health, -
[8] RahmanM,TondelM,AhmadSA,AxelsonO, .Diabetes Mellitus Associated with Arsenic Exposure in Bangladesh,Am J Epidemiol 148 -
[9] TsengCH,TaiTY,ChongCK,TsengCP,LaiMS,LinBJ, 2000.Long-term arsenic exposure and incidence of non-insulindependent diabetes mellitus: a cohort study in arseniasishyperendemic villages in Taiwan,Environ Health Perspect 108 847 -51
[10] HopenhaynC,BushHM,BingcangA,Hertz-PicciottoI, 2006.Association between arsenic exposure from drinking water and anemia during pregnancy,J Occup Environ Med 48 635 -43
[11] SanghamitraS,HazraJ,UpadhyaySN,SinghRK,AmalRC, .Arsenic induced toxicity on testicular tissue of mice,Indian J Physiol Pharmacol; 52 84 -90
[12] LongneckerMP,DanielsJL, 2001.Environmental contaminants as etiologic factors for diabetes,Environ Health Perspect 871 -6
[13] TsengC H,TsengC P,ChiouH Y,Hsueh Y M , Chong C K,Chen C J., .Epidemiologic evidence of diabetogenic effect of arsenic, 133 69 -76
[14] KapajS,PetersonH,LiberK,Bhattacharya P. Human Health Effects From Chronic Arsenic Poisoning-A Review. J Environ Sci Heal PartA ., 2006., 41 2399 -428
[15] JhalaDD,NairSB,ChinoyNJ, 2004.Reversible toxicity of fluoride and arsenic in ovary of mice,Fluoride 37 71 -9
[16] SinghS,RanaSVS, 2007.Amelioration of arsenic toxicity by LAscorbic acid in laboratory rat,J Environ Biol -
[17] JalaludeenAM,HaWT,LeeR,KimJH,DoJT,ParkC, 2016.Biochanin a ameliorates arsenic-induced hepatoand hematotoxicity in rats,Molecules 21 1 -14
[18] SharmaA,SharmaMK,KumarM., 2007.Protective effect of Mentha piperita against arsenic-induced toxicity in liver of Swiss albino mice,Basic Clin Pharmacol Toxicol 100 249 -57
[19] GuptaR,FloraSJS, 2005.Protective value of Aloe vera against some toxic effects of arsenic in rats,Phyther Res 19 23 -8
[20] CiceraleS,LucasL,KeastR, 2012.Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil,Curr Opin Biotechnol 23 129 -35
[21] KharroubiW,DhibiM,HaouasZ,ChreifI,NeffatiF,HammamiM, 2014.Effects of sodium arsenate exposure on liver fatty acid profiles and oxidative stress in rats,Environ Sci Pollut Res 21 1648 -57
[22] FaragRS,El-BarotyGS,BasunyAM, 2003.Safety evaluation of olive phenolic compounds as natural antioxidants,Int J Food Sci Nutr 54 159 -74
[23] KakarS,KamathPS,BurgartLJ, 2004.Sinusoidal dilatation and congestion in liver biopsy: Is it always due to venous outflow impairment?,Arch Pathol Lab Med 128 901 -4
[24] OyagbemiAA,OmobowaleTO,AsenugaER,AfolabiJM,AdejumobiOA,AdedapoAA, 2017.Effect of arsenic acid withdrawal on hepatotoxicity and disruption of erythrocyte antioxidant defense system,Toxicol Reports 4 521 -9
[25] AzabAE,AlbashaMO, 2018.Hepatoprotective Effect of Some Medicinal Plants and Herbs against Hepatic Disorders Induced by Hepatotoxic Agents,J Biotechnol Bioeng 2 8 -23
[26] BashirS,SharmaY,IrshadM,GuptaSD,DograTD, 2006.ArsenicInduced Cell Death in Liver and Brain of Experimental Rats, 38 -43
[27] 2000.Histopatholog1cal study of liver 6.1, -
[28] DasS,PradhanGK,DasS,NathD,Das SahaK., .Enhanced protective activity of nano formulated andrographolide against arsenic induced liver damage,Chem Biol Interact -
[29] KularatneSAM,ImbulpitiyaIVB,AbeysekeraRA,WadugeRN,RajapakseRPVJ,WeerakoonKGAD, 2014.Extensive haemorrhagic necrosis of liver is an unpredictable fatal complication in dengue infection: A postmortem study,BMC Infect Dis 14 1 -10
Citations
Citations are not available for this document.
0

Citations

0

Downloads

3

Views