Abstract:
To see the toxic effects of NSAID on kidney tissue of albino rats. Methods: For this experimental study, 16 albino rats were taken. They were divided into two groups; Aand B. The animals in group-Awere given Normal Saline. Group-B received Diclofenac Sodium 2 mg/kg/day by feeding tube for 14 days. On day-15 all animals were sacrificed. Kidneys were removed, fixed, embedded in paraffin,section cut at 4 µm thick and stained with H&E, PAS, and silver methenamine. Renal histology was done underlight microscope to see the renal tubular diameter, count and cellular detail. Results: The result of present study revealed that diclofenac sodium in single daily dose of 2 mg/kg for a period of two weeks effectively produced destruction of proximal and distal convoluted tubules in adult albino rats showing the dilatation of tubule and flattening of tubular epithelium, disruption of brush border in proximal tubuleand thickening of basement membrane around proximal and distal tubular epithelium. Conclusion: Diclofenac sodium induced nephrotoxicity causes the destruction of proximal and distal convoluted tubules showing the dilatation of tubule and flattening of its epithelium in albino rats.
Page(s):
349-351
DOI:
DOI not available
Published:
Journal: Journal of Pakistan Medical Association, Volume: 57, Issue: 7, Year: 2007