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Variations in clinical presentation, neuroimaging and eeg patterns of subacute sclerosing panencephalitis
Author(s):
1. Areeba Wasim: Children’s Hospital & Institute of Child Health, Lahore, Pakistan
2. Javeria Raza Alvi: Children’s Hospital & Institute of Child Health, Lahore, Pakistan
3. Natasha Ghani: Children’s Hospital & Institute of Child Health, Lahore, Pakistan
4. Athar Khalily: Children’s Hospital & Institute of Child Health, Lahore, Pakistan
5. Zia Ur Rehman: Children’s Hospital & Institute of Child Health, Lahore, Pakistan
6. Tipu Sultan: Children’s Hospital & Institute of Child Health, Lahore, Pakistan
Abstract:
Objective: To determine the variations in clinical presentation, neuroimaging and electroencephalography patterns of subacute sclerosing panencephalitis. Study Design: Cross-sectional study. Place and Duration of Study: Children's Hospital & Institute of Child Health, Lahore, Pakistan, from Jul to Dec 2020. Methodology: We recruited children presented with clinical features suggestive of subacute sclerosing panencephalitis, along with positive anti-measles antibodies on cerebrospinal fluid. Association between variables was determined to formulate an early diagnosis of subacute sclerosing panencephalitis. Results: Out of 47 children, 29 were males with a mean age of 6.54 ± 2.9 years. Only 23% were fully immunized against measles, 36.2% were unvaccinated and 40.4% received partial immunization. The mean age of measles infection was 1.49 ± 1.2 years; the mean interval between measles and onset of SSPE was 4.13 ± 3 years. Atypical clinical presentation was seen in 38.3% with intractable epilepsy (8.5%), focal deficit (8.5%) and extrapyramidal symptoms (8.5%) being commonest followed by coma (6.4%), visual loss (4.3%) and psychosis (2.1%). Neuroimaging was suggestive of cortical hyperintensities in 46.8% and was normal in 46.8%. Electroencephalography showed burst suppression in 55.3% and atypical findings in 19.1%. Younger age (1-1.5 years) of measles and unimmunized status were associated with early onset of SSPE with a p-value of 0.001 and 0.05 respectively. Non-immunized status was associated with atypical presentation of SSPE (p-value <0.05). Conclusion: The younger age of measles infection and failure to receive complete immunization led to early onset of Subacute sclerosing panencephalitis with an atypical presentation.
Page(s): 1839-1843
Published: Journal: Pakistan Armed Forces Medical Journal, Volume: 71, Issue: 5, Year: 2021
Keywords:
electroencephalography , Antimeasles antibodies , Subacute sclerosing panencephalitis
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