Author(s):
1. Neelam Manzoor:
PUMHS SHAHEED BENAZIRABAD. Sindh Pakistan
2. Parus Saleem:
PUMHS SHAHEED BENAZIRABAD. Sindh Pakistan
3. Khan Muhammad Nangrejo:
PUMHS SHAHEED BENAZIRABAD. Sindh Pakistan
4. Amjad Sahito:
PUMHS SHAHEED BENAZIRABAD. Sindh Pakistan
5. Ayesha khan:
PUMHS SHAHEED BENAZIRABAD. Sindh Pakistan
6. Sikandar Mirza:
PUMHS SHAHEED BENAZIRABAD. Sindh Pakistan
Abstract:
Introduction: In the modern era of industrialization and global seasonal change, human health has been adversely affected. One of its sequels is ocular allergy. Objective: To evaluate the efficacy and safety of (0.03%) tacrolimus skin ointment in patients with moderate to severe refractory vernal keratoconjunctivitis (VKC). Study Design: Prospective interventional study. Setting & Duration: Ophthalmology outpatient department (OPD) Peoples University of Medical and Health Sciences from 16 February 2019 to 16 August 2021. Material &Methods: 200 patients suffering from moderate to severe VKC were selected, based on TSSS (Total subjective scoring system) and TOSS total objective scoring system). The study participants were separated into 2 groups (100 each) withtreatment group receiving0.03% Tacrolimus ointment while the other receiving conventional therapy. To determine the effectiveness (measured by the change mostly in clinical condition), a randomised clinical investigation was carried out and safety (safe treatment from development of any complications or side effects) of Tacrolimus ointment in comparison with conventional therapy. Result: It was observed that 73% patients had tarsal form of VKC, 24% had limbal and 3% had mixed (both) types of disease. Every one of the patients had complete subjective symptom severity ratings (TSSS) and total objective ocular severity scores (TOSS) which ranged among 2 & 3. Treatment with either 0.03% Tacrolimus or conventional group was found to be effective in eradicating the symptoms of VKC measured by TSSS scores. Conclusion: Among the medical therapies used in this study it is found that, Tacrolimus ointment 0.03% was more nontoxic & actual in eradicating the severity of signs and symptoms of the vernal keratoconjunctivitis evident by the TSSS and TOSS scores. (ASM allergic systemic manifestations)rhinitis, asthma and eczema)
Page(s):
58-67
Published:
Journal: journal of Peoples University of medical and Health Sciences, Pakistan., Volume: 13, Issue: 1, Year: 2023
Keywords:
Tacrolimus
,
Vernal keratoconjunctivitis
,
TOSS total objective ocular scoring system ASM Associated Syestemic manifestation
,
TSSS total subjective scoring system
References:
References are not available for this document.
Citations
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