A Systematic Review on Nanomedicine | [Pakistan Journal of Medical and Health Sciences • 2022]

Author(s):

1. YASIR NAWAZ: Department of Soil and Environmental Sciences, the University of Agriculture, Peshawar, Pakistan

2. ISHART NAZAR: Department of Zoology, University of Okara, Okara Pakistan.

3. HASSNAIN AHMAD: Department of Botany, University of Agriculture Faisalabad,Pakistan

4. MUHAMMAD SALEEM KHAN: Department of Zoology, University of Okara,Okara,Pakistan

5. LUQMAN HAKEEM: Department of Chemistry, University of Agriculture Faisalabad,Pakistan

6. AYESHA SADDIQA: Department of Chemistry, University of Agriculture Faisalabad, Pakistan

7. MUHAMMAD KALEEM ULLAH: Department of Zoology, University of Okara, Okara Pakistan.

8. HAFIZA RABIA SHAFIAQ: Department of Zoology, University of Okara, Okara Pakistan.

9. KHADIJA IQBAL: Department of Zoology, University of Okara, Okara Pakistan.

10. MUHAMMAD WAIJAD: Department of Zoology, University of Okara, Okara Pakistan.

11. BILAL SAEED: Department of Zoology, University of Okara, Okara Pakistan.

Abstract:

Nanomedicine is used to cure cancer of many tissues such as ovarian cancer and multiple myeloma. With the help of nanotechnology, the probability of failure or rejection of a transplant, an organ is reduced. Nanomedicine is one of the latest and better fields which is used for the treatment of tumors. Some of the methods used to produce nanoparticles are discussed here. Many nanoparticles are used for the benefit of humans. The solvent is subsequently dispersed in a surfactant's aqueous media, resulting in the formation of a film in an instant colloidal suspension called solvent displacement. This method can be used to achieve a pharmacological payload. Supersaturation and precipitation are required for the assembly and stability of drug nanoparticles. Shear and cavitation forces are also used to produce nanoparticles. The milling media is generating shear forces on impact, resulting in nanoparticles, the principle of size reduction. Extrusion is also used to generate nanoparticles. Hydrophobic drugs are converted directly into nanoparticles. The capacity to build nanocores with a wide range of functionalities is another key advantage of the HAylation process (a method to make nanoparticles). Determine medication, metabolism and hepatotoxicity in these models in nanomedicine have the potential to have a significant influence in the field. Red blood cells (RBCs), for example, are sensitive to substantial external flow pressures, and their inherent formability can be used as a biomarker to identify a range of RBC diseases. It is concluded that different nanoparticles are made to treat different kinds of diseases and to make different therapies for cancer etc. Now a day's nanotechnology is the method that uses nanoparticles to cure diseases and provide a significant treatment approach to humans.

Page(s): 2-5

DOI: 10.53350/pjmhs221652

Published: Journal: Pakistan Journal of Medical and Health Sciences, Volume: 16, Issue: 05, Year: 2022

Keywords:

Nanoparticles , Nanomedicine , nanotechnology , nanotherapeutics , production of nanomedicine

References:

[1] Kang Y. .1996 .'Synthesis and characterization of nanometer-size Fe3O4 and g-Fe2O3 particles' Chem. , 50(8) : 2209-2211.

[2] Pankhurst Q. .2003 .'Applications of magnetic nanoparticles in biomedicine'. J. Phys. D. Appl. Phys, 36(2) : 167-176.

[3] Dobson J. .2006 .'Gene therapy progress and prospects: magnetic nanoparticle-based gene delivery'. , 13(1) : 283-287.

[4] Rudge S.,Control S. .2001 .'Adsorption and desorption of chemotherapeutic drugs from a magnetically targeted carrier'. , 74(23) : 335-340.

[5] Mody V. .2010 .'Introduction to metallic nanoparticles'. J. Pharm. Bioallied. Sci.: 2, : 282-289.

[6] Zarbin M. .2010 .'Nanotechnology in ophthalmology'. Can. J. Ophthalmol.: 45, : 457-476.

[7] Jain K.,K. K. .2003 .'Application of nanotechnology in molecular diagnostics'. Expert Rev. Mol. Diagn.: 3, 358(8) : 153-161.

[8] Singh R. .2010 .'Application of peptide nucleic acid towards development of nanobiosensor arrays'. Eur. Comm.: 79, : 153-161.

[9] Garelnabi M. .2016 .'Vision Paper and Basis for a Strategic Research Agenda for Nanomedicine'. Eur. Comm.: 23(1), : 1-39.

[10] Debouck C. .1999 .'DNA microarrays in drug discovery and development'. Nat. Genet, 21(44) : 48-50.

[11] Cole K. .2009 .The genetics of cancer': Nat. , 21(3) : 38-41.

[12] Babu R.,Palakurthi R. J.,S. R. J. .2014 .Nanomedicine scaleup technologies: feasibilities and challenges. Aaps Pharmscitech, 15(6) : 1527-1534.

[13] Yu Q.,Ye J.,Zhang M.,Gao C.,Zhang F.,X. Z. F. .2020 .Establishment of Facile Nanomedicine Construction Methodology to Comprehensively Overcome Hurdles across Tumor‐Specific Nano‐Delivery. Advanced Functional Materials, 30(49) : 2002239.

[14] Rodrigues R. O,Sousa P. C.,Gaspar J.,Bañobre‐López M.,Lima R.,Minas G. .2020 .Organ‐on‐a‐Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine. , 16(51) : 2003517.

[15] Yamanluirt G.,Berns E. J.,Xue A.,Lee A.,Bagheri N.,Mrksich M.,Mirkin C. A. .2020 .Exploration of the nanomedicine-design space with high-throughput screening and machine learning. In Spherical Nucleic Acids, : 1687-1716.

[16] Banik B. L.,Fattahi P.,Brown J. L. .2016 .Polymeric nanoparticles: the future of nanomedicine. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 8(2) : 271-299.

[17] Caron S.,Papa F.,Rossi P.,Veglianese P. .2014 .Nanovector-mediated drug delivery for spinal cord injury treatment'. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 6 : 506-15.

[18] d'Angelo M.,Castelli V.,Benedetti E.,Antonosante A.,Catanesi M.,Dominguez-Benot R.,Pitari G.,Ippoliti R.,Cimini A. .2019 .Theranostic Nanomedicine for Malignant Gliomas'. Front Bioeng Biotechnol, 7 : 325.

[19] Demming A. .2013 .. Nanotechnology, 24 : 020201.

[20] Dong X.,Sun Z.,Liang J.,Wang H.,Zhu D.,Leng X.,Wang C.,Kong D.,Lv F.,Biology, F. .2018 .Corrigendum to "A visible fluorescent nanovaccine based on functional genipin crosslinked ovalbumin protein nanoparticles". and Medicine, 14 : 102524-1098.

[21] Egorov C.,Pieters H.,Korach-Rechtman J.,Shklover J.,Schroeder A. .2021 .'Robotics, microfluidics, nanotechnology and AI in the synthesis and evaluation of liposomes and polymeric drug delivery systems'. Drug Deliv Transl Res, 11 : 345-52.

[22] Hajialyani M.,Tewari D.,Sobarzo-Sanchez E.,Nabavi S. M.,Farzaei M. H.,Abdollahi M. .2018 .Natural product-based nanomedicines for wound healing purposes: therapeutic targets and drug delivery systems'. Int J Nanomedicine, 13 : 5023-43.

[23] Jain K. K. .2005 .. Clin Chim Acta, 358 : 37-54.

[24] Kenzaoui B. H.,Bernasconi C. C.,Hofmann H.,L. H. .2012 .'Evaluation of uptake and transport of ultrasmall superparamagnetic iron oxide nanoparticles by human brain-derived endothelial cells'. Nanomedicine (Lond), 7 : 39-53.

[25] Kumar A.,Nanda A. .2021 .Crystal Engineering from a Nanotechnological Perspective'. Curr Pharm Des, 27 : 2445-53.

[26] Ma X.,Sanchez S. .2017 .Self-propelling micro-nanorobots: challenges and future perspectives in nanomedicine'. Nanomedicine (Lond), 12 : 1363-67.

[27] Gimenez Martin,V. M. Martin,Kassuha D. E.,Manucha W. .2017 .Nanomedicine applied to cardiovascular diseases: latest developments'. Ther Adv Cardiovasc Dis, 11 : 133-42.

[28] Ottonelli I.,Duskey J. T.,Rinaldi A.,Grazioli M. V.,Vandelli M. A.,Wang L. Z.,Prud'homme R. K.,Ruozi B. .2021 .Microfluidic Technology for the Production of Hybrid Nanomedicines'. , 13 : .

[29] Pai N. P.,Karellis A.,Kim J.,Peter T.,Lancet HIV .2020 .Modern diagnostic technologies for HIV'. , 7 : e574-e81.

[30] Paliwal R.,Babu R. J.,Palakurthi S. .2014 .Nanomedicine scaleup technologies: feasibilities and challenges'. AAPS PharmSciTech, 15 : 1527-34.

[31] Rodrigues R. O.,Sousa P. C.,Gaspar J.,Banobre-Lopez M.,Lima R.,Minas G. .2020 .Organ-on-a-Chip: A Preclinical Microfluidic Platform for the Progress of Nanomedicine'. , 16 : e2003517.

[32] Salvador-Morales C.,Grodzinski P. .2022 .Nanotechnology Tools Enabling Biological Discovery'. , : .

[33] Soares S.,Sousa J.,Pais A.,Vitorino C. .2018 .. Front Chem, 6 : 360.

[34] Tan S.,Wang L.,Wu H.,Liu Q. .2016 .Single Nanoparticle Translocation Through Chemically Modified Solid Nanopore'. Nanoscale Res Lett, 11 : 50.

[35] Tosi G.,Vandelli M. Angela,Ruozi B. .2021 .Nanomedicines for brain diseases: where we are and where we are going'. Ther Deliv, 12 : 631-35.

Citations

Downloads

Views