A study of insulin resistance in obese and non-obese healthy first degree relatives (FDRs) of type-2 diabetes mellitus patients. | [Pakistan Postgraduate Medical Journal • 2004]

Author(s):

1. Nasir Ali: Department of Biochemistry, Wah Medical College, POF Hospital, Wah Cant, Pakistan; Department of Pathology, Ayub Medical College, Abbottabad, Pakistan; Federal Postgraduate Medical Institute, Shaikh Zayed Hospital, Lahore Pakistan

2. Naema Afzal: Department of Biochemistry, Wah Medical College, POF Hospital, Wah Cant, Pakistan; Department of Pathology, Ayub Medical College, Abbottabad, Pakistan; Federal Postgraduate Medical Institute, Shaikh Zayed Hospital, Lahore Pakistan

3. S. Shah Jahan: Department of Biochemistry, Wah Medical College, POF Hospital, Wah Cant, Pakistan; Department of Pathology, Ayub Medical College, Abbottabad, Pakistan; Federal Postgraduate Medical Institute, Shaikh Zayed Hospital, Lahore Pakistan

4. M. Zamir Ahmad: Department of Biochemistry, Wah Medical College, POF Hospital, Wah Cant, Pakistan; Department of Pathology, Ayub Medical College, Abbottabad, Pakistan; Federal Postgraduate Medical Institute, Shaikh Zayed Hospital, Lahore Pakistan

5. Abdul-Baseer: Department of Biochemistry, Wah Medical College, POF Hospital, Wah Cant, Pakistan; Department of Pathology, Ayub Medical College, Abbottabad, Pakistan; Federal Postgraduate Medical Institute, Shaikh Zayed Hospital, Lahore Pakistan

Abstract:

The study included 45 healthy first degree relatives (FDRs) of type 2 diabetes mellitus (T2DM) patients, 24 males and 21 females between ages 25-45 years. Thirty age matched controls not related to diabetics were also included in the study. Both subjects-FDRs and controls were further divided into obese and non obese groups. The BMI in obese and non-obese male subjects-FDRs were significantly high and showed a positive correlation with % body fat, whereas in case of female subjects-FDRs; the BMI showed a positive correlation with % body fat in non obese female subjects-FDRs and non obese controls only but not in obese female subjects-FDRs. The fasting and 2 hour serum insulin levels were high in all subjects-FDRs groups indicating development of insulin resistance in subjects-FDRs of T2DM. A significant positive correlation between fasting insulin levels and % body fat in non-obese male and female subjects-FDRs were observed which was not seen in respective controls. In non obese group, the male subjects-FDRs did not show a significant high FPG and in obese group, only the obese male subjects-FDRs showed significantly high FPG. The 2 hour PG was significantly high in non obese male and female subjects-FDRs as compared to respective controls. The FPG and 2 hour PG showed a positive correlation with fasting and 2 hour insulin level in non obese female subjects-FDRs only but not in other groups. A significant negative correlation between 2 hour insulin levels and BMI in obese male subjects-FDRs was observed which was not seen in respective controls group.

Page(s): 81-92

DOI: DOI not available

Published: Journal: Pakistan Postgraduate Medical Journal, Volume: 15, Issue: 2, Year: 2004

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