A comparative study on the contractile behaviour of denervated skeletal muscles of rat and uromastix. | [International Journal of Pharmacology • 1993]

Author(s):

1. Khairun-Nissa Shaikh: Pharmacology Department, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

2. M. Abdul Azeem: Neuromuscular Physiology Unit, Department of Physiology, University of Karachi, Karachi, Pakistan

3. S. Arifa: Neuromuscular Physiology Unit, Department of Physiology, University of Karachi, Karachi, Pakistan

4. N. Shahina: Neuromuscular Physiology Unit, Department of Physiology, University of Karachi, Karachi, Pakistan

5. Hilal A. Shaikh: Neuromuscular Physiology Unit, Department of Physiology, University of Karachi, Karachi, Pakistan

Abstract:

Studies regarding the effects of disuse on the skeletal muscles of rat and uromastix were made in view of the differences already reported in the contractile characteristics of the normal skeletal muscles of uromastix (Azeem and Shaikh, 1987). The left hemi-diaphragm of white albino rat and the left gastrocnemius muscles of uromastix were chronically denervated for 21 days. In rats, the twitch and tetanic tensions of the denervated muscles showed significant decreases. However, Other time dependent parameters were found to be increased significantly. In case of uromastix however, the muscles were not found to be affected by chronic denervation. The contractile behaviour of the denervated muscles of these animals are discussed in terms of morphological and mechanical contraction differences.

Page(s): 55-63

DOI: DOI not available

Published: Journal: International Journal of Pharmacology, Volume: 10, Issue: 1, Year: 1993

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