Author(s):
1. Nema M. El-Abd:
Harmful Animals Research Department, Plant Protection Research Institute, Agriculture Research Center (ARC),Dokki, Giza,Egypt
2. Randa A. Kandil:
Harmful Animals Research Department, Plant Protection Research Institute, Agriculture Research Center (ARC),Dokki, Giza,Egypt
3. Heba Y. Ahmed:
Harmful Animals Research Department, Plant Protection Research Institute, Agriculture Research Center (ARC),Dokki, Giza,Egypt
Abstract:
This study aims to assess the impact of clodinafop-propargyl herbicide on black rat (Rattus rattus L.). It was tested as bait using non- and free choice feeding method. Serial concentrations of the tested compound as bait were offered to rats through non-choice feeding technique during different periods to detect the most effective bait concentration gives high mortality percent. The results depicted that the best bait concentration which gave 100% mortality was 0.98% and the time of death ranged between 5-15 days with 6.2 days mean. The acceptance of tested bait was examined by free choice feeding technique and it was 45.83% with 100% mortality and the time of death ranged between 10-16 days with 6.7 days mean. The clinical symptoms were a reduce in body weight, loss of water through the skin, slow movement and loss of appetite of rats as well as increase in heart and lung weights. Additionally, cardiac hypertrophy and pulmonary hemorrhage as a result of treatment has been observed. Studying toxic action revealed that, 1/4 LD50 (348 mg/kg b. wt.) oral administration of clodinafop-propargyl after seven days caused remarkable increase in serum levels of lactate dehydrogenase (LDH) and malondialdhyde (MDA), but it caused marked decrease in total protein, total lipids and glutathione (GSH) contents. This disruptive effect is supported by histopathological changes in heart and lung tissues. Furthermore, application of the tested bait 0.98% of clodinafop-propargyl in poultry farm conditions achieved 87.77% reduction in rat population. So, it is taken into regard that clodinafop-propargyl bait has a strong effect against rats as it caused destruction of heart and lung tissue and motivation of oxidative stress leading to death.
Page(s):
405-412
Published:
Journal: International Journal of Agriculture and Biology, Volume: 28, Issue: 6, Year: 2022
Keywords:
oxidative stress
,
histopathology
,
Rattus rattus
,
Field application
,
Clodinafoppropargyl
,
Freechoice feeding
References:
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