The journey from viral hepatitis to hypocythemia: Two case reports | [Journal of Pakistan Medical Association • 2023]

Author(s):

1. Hassan Ur Rehman: Department of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.

2. Ayesha Javed: Department of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.

3. Nabeel Tariq: Department of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.

4. Nida Zeb Abbasi: Department of Internal Medicine and Endocrinology, Pakistan Institute of Medical Sciences / Shaheed Zulfiqar Ali Bhutto Medical University, Islamabad, Pakistan.

Abstract:

Acute viral hepatitis, including hepatitis A, B, E, D, and G, can lead to severe bone marrow suppression due to cytotoxic lymphocytes. The bone marrow suppression causes aplastic anaemia which is mostly unresponsive to immunosuppressive therapy. Such patients require bone marrow transplant for a complete cure. The pancytopenia can evolve during recovery from transaminitis. We are presenting two case reports relating aplastic anaemia with acute viral hepatitis in two young patients-23 and 16 years of age. The 23-year-old female patient had hepatitis A associated with aplastic anaemia whereas the young 16year-old male patient was diagnosed with Hepatitis E IgG associated aplastic anaemia. Unfortunately, the fi rst patient could not cope with the complications relating to pancytopenia and was unable to reach the bone marrow transplant stage. The second patient did not have a bone marrow transplant but showed an excellent response to immunosuppressive therapy before the transplant and survived.

Page(s): 419-423

DOI: DOI not available

Published: Journal: Journal of Pakistan Medical Association, Volume: 73, Issue: 2, Year: 2023

Keywords:

Aplastic anaemia , Pancytopenia , Viral Hepatitis , Hepatitis A , hepatitis E , Bone marrow failure

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