Analgesic and anxiolytic evaluation of N-substituted arylsulphonyl and benzoyl derivatives of 4-pyridine carbohydrazide. | [FUUAST Journal of Biology • 2014]

Author(s):

1. Sabahat Naeem: Dow College of pharmacy, Dow University of Health Sciences (DUHS), Karachi, Pakistan

2. Shamim Akhtar: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

3. Nousheen Mushtaq: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

4. Arfa Kamil: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology (FUUAST), Gulshan-e-Iqbal Campus, Karachi, Pakistan

5. Iffat Mahmood: Department of Chemistry, Faculty of Science, Federal Urdu University of Arts, Science and Technology (FUUAST), Gulshan-e-Iqbal Campus, Karachi, Pakistan

6. Shaista Zafar: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

7. Muhammad Arif: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan

8. Z. S. Saify: HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS), University of Karachi, Karachi, Pakistan

Abstract:

4-Pyridine carbohydrazide (4-PCH) and its synthetic derivatives divulged an array of pharmacological activities. In continuation of our search for development of new potent and effective drug candidates, this study was aimed to investigate the previously synthesized N'-substituted arylsulphonyl and benzoyl derivatives of PCH for analgesic and anxiolytic effects by known experimental protocols. It was found that only N'-[(4- methylbenzene) sulfonyl]pyridine-4-carbohydrazide (1) exhibited analgesia at the dose of 25 mg/Kg body weight in tail flick test. In open field test (OFT), it was observed that N'-[(4-bromobenzene)sulfonyl]pyridine-4- carbohydrazide (3), N'-[(4-nitrobenzene)sulfonyl]pyridine-4-carbohydrazide (4) and N´-[4-methylbenzoyl) ]pyridine-4-carbohydrazide (5) showed anxiolytic like behavior. Structure Activity Relationship (SAR) was also ascertained.

Page(s): 123-126

DOI: DOI not available

Published: Journal: FUUAST Journal of Biology, Volume: 4, Issue: 2, Year: 2014

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