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Therapeutic Drug Monitoring of Broad Spectrum Antifungal, Voriconazole- a Review.
Author(s):
1. Saba Mazhar: Department of Pharmaceutical services, Shaukat Khanum Memorial Cancer and Research Hospital, Lahore, Pakistan
2. Umar Zia: Department of Pharmaceutical services, Shaukat Khanum Memorial Cancer and Research Hospital, Lahore, Pakistan
3. Umar Farooq Gohar: Department of Pharmaceutics, Riphah Institutes of Pharmaceutical Sciences, Lahore, Pakistan
4. Ayesha Rahman: Department of Pharmaceutical services, Shaukat Khanum Memorial Cancer and Research Hospital, Lahore, Pakistan
5. Ehsan Elahi: Department of Pharmaceutical services, Shaukat Khanum Memorial Cancer and Research Hospital, Lahore, Pakistan
6. Nouman Saleem: Department of Pharmaceutical services, Shaukat Khanum Memorial Cancer and Research Hospital, Lahore, Pakistan;Department of Clinical Pharmacy, Punjab University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, Pakistan
7. Maryam Qamar: Department of Clinical Pharmacy, Punjab University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, Pakistan
8. Faiza Azhar: Department of Clinical Pharmacy, Punjab University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, Pakistan
9. Zikria Saleem: Department of Clinical Pharmacy, Punjab University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, Pakistan
Abstract:
Voriconazole is a broad-spectrum antifungal drug. It belongs to triazole group, and is available in market as oral as well as intravenous (IV) forms. It is highly effective against a number of clinically important fungi causing invasive infections. Its pharmacokinetic profile is non-linear with extensive inter-individual and intra-individual variability. Various factors contribute towards this variability including age, race, gender, genotype, hepatic functions, administration with or without food, and concomitant administration of other drugs causing drug interactions. Variability in plasma concentrations of the drug, arising from these factors, may result in variations in efficacy of the drug or may contribute towards potential toxicity. Voriconazole therapeutic drug monitoring is mandatory considering bad prognosis of patients suffering from invasive fungal infections, especially ones who are immunosuppressed, and prolonged period of treatment needed, in order to optimize antifungal treatment and to prevent the adverse events.
Page(s): 35-39
DOI: DOI not available
Published: Journal: Pakistan Journal of Pharmacy, Volume: 30, Issue: 1, Year: 2017
Keywords:
Keywords are not available for this article.
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