Abstract:
The aim of the study was to compare the efficacy and safety of topical Tacrolimus ointment with that of Triamcinolone Acetonide ointment on patients suffering from oral lichen plan us. A total of sixty patients (53 females and 07 males, means age 48 years; 30 patients per groups) were treated with Tacrolimus, a calcineurin inhibitor immunosuppresor drug and Triamcinolone acetonide for three months in a randomized clinical trial. Thirty patients (group 1) were treated with topical Tacrolimus (0.1 %, 0.003%) ointment four times daily and thirty patients (group II) were treated with Triamcinolone Acetonide 0.1% ointment four times daily. The clinical effects were graded after 1, 2, and 3 months of treatment. Visual analogue scale 0-10 was used to access the severity of pain before and after treatment. In group 1, Sixteen patients showed healed lesion, 10 showed improvement and 4 showed no improvement. In group II, 5 were healed, 9 patients showed 50% improvement and 16 showed no improvement. No side effects of these drugs were reported in these patients. Topical tacrolimus ointment induced a better initial therapeutic response than Triamcinolone acetonide ointment. However, relapse occured in 12 cases within 6-8 weeks of the cessation of the therapy
Page(s):
19-21
DOI:
DOI not available
Published:
Journal: Pakistan Oral and Dental Journal, Volume: 30, Issue: 1, Year: 2010