A study of Linear Growth in β-Thalassaemia Major Patients: A cross-sectional study from Hereditary Blood Disorders Centre in Babylon | [Pakistan Paediatric Journal • 2022]

Author(s):

1. Rebee Mohsin: Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Babylon, Iraq

2. Amal Salih Bayee: Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Babylon, Iraq

3. Hayder Abdul-Amir Al-hindy: Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Babylon, Iraq

4. Mazin Jaafar Mousa: Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Babylon, Iraq

5. Fouad Shareef Dleikh: Department of Pharmacology and Toxicology, College of Pharmacy, University of Babylon, Babylon, Iraq

Abstract:

Objective: To investigate the growth status among ß-Thalassaemia Major patients attending Hereditary Blood Disorders Centre in Babylon, Iraq. Study Design: This cross-sectional study. Place and Duration of Study: Hereditary Blood Disorders Centre in Babylon, Iraq from July 2019 to December 2020. Material and Methods: 163 ß-ThM patients aged 3-17 years. The anthropometric measures were plotted on the most agreed international growth charts for a growth evaluation. A Z-score of <-2 height is considered as short stature and a Z-score <-2 BMI measures as underweight for age. SPSS/version-25 was applied to analyze the data. Results: The mean ages were 12.6 ± 3.5 and eighty-four (51.5%) were males. The mean weight, height, body mass index, height Zscore, and weight Z-score were 136.9 ± 15.1, 32.5 ± 10.3, 16.8 ± 3.3, 2.1 ± 1.1, and 2.0 ± 1.3, respectively. Around a third of the patients were suffering from stunted growth. Males' heights seem to be affected more. There was a significant association among anthropometric results with the increasing age of ß-ThM patients (p-0.003). A significant incidence of GR was observed among patients aged > 9 years (p-0.001). Conclusion: The GR in terms of delayed linear growth, weight, and BMI are common health issues in ß-ThM that become apparent after 10years of age. The male seems to show a significant linear-growth delay. Patients with ß-ThM necessitate regular transfusions regimen and improved policies for iron overload.

Page(s): 404-409

DOI: DOI not available

Published: Journal: Pakistan Paediatric Journal, Volume: 46, Issue: 4, Year: 2022

Keywords:

Linear Growth , Betathalassaemia major , growth retardation

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