Synthesis, optimization and biological evaluation of 99m Tc-Digoxin as possible cardiac imaging agent. | [Pakistan Journal of Pharmaceutical Sciences • 2018]

Author(s):

1. Tanveer Hussain Bokhari: Department of Chemistry, Government College University,Faisalabad,Pakistan

2. Samina Roohi: Isotope Production Division, Pakistan Institute of Nuclear Science and Technology,P.O. Nilore, Islamabad,Pakistan

3. Saira Hina: Government College Women University,Faisalabad,Pakistan

4. Shabana Saeed: Pakistan Institute of Engineering and Applied Sciences,P. O. Nilore, Islamabad,Pakistan

Abstract:

Heart imaging radiopharmaceuticals could improve the diagnostic value of routine heart scanning for detecting cardiac disorders. The aim of the study was to prepare high radiochemical purity 99mTc-Digoxin in a yield of about 98%. The optimal conditions for labelling were as follows: 100µg of Digoxin, 2µg of SnCl2·2H2O, room temperature (25±1°C), reaction retention time of 30 min at pH 7. Under these conditions, the radiochemical yield of 99mTc-Digoxin reaches 98%. In vivo bio distribution was performed in normal Swiss Albino mice at different time intervals after administration of 99mTc-Digoxin.Scintigraphic study of 99mTc-Digoxin was performed in rabbits. The heart uptake of 99m Tc-Digoxin was sufficiently high and thus may be a potential myocardial imaging radiopharmaceutical applicable in cardiology.

Page(s): 19-24

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 31, Issue: 1, Year: 2018

Keywords:

99mTcDigoxin , bio distribution , chromatographic analysis

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