Synthesis, in vitro antibacterial and antifungal activity of some n-acetylated and non-acetylated pyrazolines. | [Pakistan Journal of Pharmaceutical Sciences • 2013]

Author(s):

1. Muhammad Baseer: Chemistry Department, Quaid-i-azam University, Islamabad, Pakistan

2. Farzana Latif Ansari: Chemistry Department, Quaid-i-azam University, Islamabad, Pakistan

3. Zaman Ashraf: Chemistry Department, Allama Iqbal Open University, Islamabad, Pakistan

Abstract:

Fourteen new N-acetylated and non-acetylated pyrazoline derivatives were synthesized by reacting chalcones with hydrazine in the presence of absolute ethanol however reaction was carried out in the presence of glacial acetic acid to afford N-acetylated pyrazolines. The chemical structures of the synthesized pyrazolines were confirmed by FTIR, (1)HNMR, (13)CNMR and mass spectroscopic data. The pyrazolines (1-14) were screened for antibacterial activity against ten bacterial strains using seven Gram-positive and three Gram-negative bacteria and antifungal activity against Aspergillus flavus, Aspergillus niger and Aspergillus pterus. Pyrazolines (1-14) found to exhibit good to excellent antimicrobial activities compared to the levofloxacin and fluconazole used as standard drugs.

Page(s): 67-73

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 26, Issue: 1, Year: 2013

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