Abstract:
Medicinal plants have been utilized for centuries to treat human diseases. Traditional uses of medicinally important plants are gaining a lot of attention of new researchers to develop new drugs and formulations. Crude extracts and nanoparticles of various plants parts are currently under investigations all over the world. The current research was designed to analyze the In Vivo therapeutical potential of different extracts of Citrullus colocynthis fruit and the synthesis of their ZnO nanoparticles. C. colocynthis is a wild desert plant, commonly known as Bitter Apple and Korh Tumba. Native people used its fruit due to its various therapeutical properties. In this study, C. colocynthis extracts were prepared in different solvents such as MtOH, DCM, EtAc and n-Hex. These extracts were investigated InVivo on Albino rats. The animals were kept according to the OECD guidelines. Acute toxicity tests reveals no mortality up to the dose 5g/kg BW. LD50 of the fruit was >5g/kg BW. Different extracts exhibit significant anti-pyretic potential in animal models against yeast induced pyrexia. The overall trend observed was EtAc>MtOH>DCM>n-Hex. The general trend observed in anti-diabetic activity was MtOH>EtAc>DCM>n-Hex. All extracts have shown the significant hypoglycaemic effects at the dose of 500mg/kg BW. MtOH was found most effective in 7 day trial. In the anti-inflammatory activity, different extracts exhibit different inhibition potentials at different time intervals, max inhibition effect was shown by MtOH extract and the trend observed was: MtOH>EtAc>DCM>n-Hex. The n-Hex extract have shown the least potential in reducing inflammation. C. colocynthis anti-nociceptive potential was investigated by analgesic methods. The general trend observed in this method is EtAc> MtOH>DCM>n-Hex. This activity reveals the potential of reducing pain symptoms without losing consciousness. Green synthesis of powdered ZnO nanoparticles with different extracts of C. colocynthis was done. The particles were confirmed and characterized by UV-Visible spectroscopy and FT-IR spectroscopy. It was concluded that C. colocynthis fruit have excellent anti-pyretic, anti-inflammatory, analgesic and anti-diabetic potentials. The study supports the ethnopharmacological importance of C. colocynthis fruit.
Page(s):
82-82
DOI:
DOI not available
Published:
Journal: Abstract Book on Global Science Technology and Management Conference, Volume: 0, Issue: 0, Year: 2023
Keywords:
Nanoparticles
,
Citrullus colocynthis
,
Green synthesis
,
Anti pyretic effects