Abstract:
This study aimed to synthesize sulfur nanoparticles using Allium cepa extract and evaluate their antibacterial and antifungal activities. The nanoparticles were characterized using zeta size, zeta potential, UV analysis, ATR-FTIR, and SEM. The prepared SNPs exhibited a globule size of 74.21 ± 1.54 nm, with a 0.278 ± 0.02 PDI value. The zeta potential value of the SNPs was -14.16 ± 0.54 mV. SNPs of Allium cepa extract showed a UV peak at 297 nm. The ATR-FTIR analysis has demonstrated that Allium cepa extract, SNPs of Allium cepa extract, and SNPs of Allium cepa extract embedded in nanocream formulation (H3a) have no significant changes in their chemical composition, indicating their compatibility with other materials. The morphology of SNPs of Allium cepa extract showed a uniform and almost round shape with 74 nm in size. The SNPs showed significant antibacterial activity against Gram-positive (Staph. aureus and Bacillus subtilis), Gram-negative (Escherichia coli and Bordetella), and antifungal activities (Candida albicans). The SNPs were also incorporated into a nanocream formulation (H3a), which exhibited good pH, homogeneity, viscosity, and spreadability. The nanocream (H3a) was found to be non-irritant to the skin and showed promising antibacterial and antifungal activities followed by enhanced wound healing activities. The study demonstrates the potential of using Allium cepa extract as a natural source for synthesizing SNPs and developing effective topical formulations for enhanced wound healing activities.
Page(s):
107-107
DOI:
DOI not available
Published:
Journal: Abstract Book on International Conference on Life Sciences (ICLS-23) 11-12 May 22-23, Volume: 0, Issue: 0, Year: 2023
Keywords:
Allium cepa
,
Sulfur nanoparticles
,
and Nanocream
,
Gram positive bacteria and Gramnegative bacteria