Adjuvant therapy in node negative breast cancer. | [Pakistan Journal of Pharmacology • 2004]

Author(s):

1. Alamgir Mohiuddin: Department of Pathology, Hamdard College of Medicine & Dentistry, Hamdard University, Karachi, Pakistan

2. Salahuddin: Department of Biochemistry, Hamdard College of Medicine & Dentistry, Hamdard University, Karachi, Pakistan

3. Qamar Jamal: Department of Pathology, Ziauddin Medical University, Clifton, Karachi, Pakistan

Abstract:

This is a retrospective and prospective study carried out in the Department of Pathology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi from October 2000 to October 2002. The objective was to assess the role of adjuvant therapy in node-negative breast carcinomas. A total of fifty-breast carcinoma specimens were investigated comprising of forty invasive ductal carcinomas and ten invasive lobular carcinomas. Ki-67 antigen was immunostained on formalin-fixed paraffin embedded tissue and the positivity index was determined. Thirty-three cases showed positive nuclear staining. In ILC, 07 lymph node positive cases had a mean Ki67 index of 13.1± 5.7% while Of lymph node negative case had a Ki-67 index of 14.3%. In IDC, 19 lymph node positive cases had a mean Ki67 index of 16.5 ± 11.0% and 06 lymph node negative cases had a mean Ki-67 index of 14.3 ± 4.5%. No significant correlation was found between Ki-67 labeling rates and overall extent of lymph node metastases. So it is concluded that the benefits of adjuvant cytotoxic therapy are independent of lymph node status.

Page(s): 1-6

DOI: DOI not available

Published: Journal: Pakistan Journal of Pharmacology, Volume: 21, Issue: 2, Year: 2004

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