The Expression of NDRG1, VEGF and Ki-67 in Condyloma acuminatum. | [RADS Journal of Pharmacy & Pharmaceutical Sciences • 2016]

Author(s):

1. Guangwen Yin: Department of Dermatology, 1st Afiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China

2. Ying Guo: Department of Dermatology, 1st Afiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China

3. Bin Jin: Department of Dermatology, 1st Afiliated Hospital of Zhengzhou University, Zhengzhou City, Henan Province, China

Abstract:

Objective: To explore the expression and significance of NDRG1, VEGF and Ki-67 in lesions of CA (Condyloma Acuminatum). Methods: SP immuno histochemistry method was used to measure the expression of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. Results: The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in CA tissues, meanwhile 27.78% (5/18), 94.44% (17/18) and 61.11% (11/18) in the controls. The intensity of expression of NDRG1, VEGF and Ki-67 in CA tissues was obviously higher (++ ~ +++) than that in normal controls (- ~ ++). There was a significant diefrence both in the positive rates and the expression intensity of NDRG1, VEGF and Ki-67 between the two groups (P <0.05). The Spearman rank correlation analysis showed that, the expression of NDRG1 protein and VEGF protein were positively correlated by the Spearman rank correlation analysis (r = 0.346, P=0.016). Conclusion: The higher expression of NDRG1 and VEGF in CA tissues, they inuflenced both the occurrence and development of CA together.

Page(s): 34-39

DOI: DOI not available

Published: Journal: RADS Journal of Pharmacy & Pharmaceutical Sciences, Volume: 4, Issue: 1, Year: 2016

Keywords:

Ki67 , NDRG1 , condyloma acuminatum , VEGF

References:

[1] PartridgeJM,Koutsky LA, 2006.Genital human papillomavirus infection in men,Lancet Infect Dis 6 21 -23

[2] Z.Kovacevic,Des R. Richardson, 2006.eTh metastasis suppressor, Ndrg-1: a new ally in the fight against cancer,Carcinogenesis 27 2355 -2366

[3] BhushanM,McLaughlinB,WeissJB, 1999.Levels of endothelial cell stimulating angiogenesis factor and vascular endothelial growth factor are elevated in psoriasis,Br J Dermatol 141 1054 -1060

[4] PottiA,MoazzamN,LangnessE, 2004.Immunohistochemica determination of HER-2/neu,c-kit(cd117),and vascular endothelial growth factor(VEGF) over expression in malignant melanoma[J],Cancer Res 130 80 -86

[5] TschanM P,ShanD J,Laedrach, 2010.NDRG1/2 expression is inhibited in primary acute myeloid leukemia,Leukemia Research 24 393 -398

[6] WangW Q,LiY H,LiW, 2009.NDRG3 is an androgen regulated and prostate enriched gene that promotes in vitro and in vivo prostate cancer cell growth,International Journal of Cancer 124 521 -530

[7] ChenB,Nelson D M,SadovskyY., 2006.N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury,Journal of Biological Chemistry 281 2764 -2772

[8] StensS,HerzogB, 2004.NDRG1 is necessary for p53-dependent apoptosis,Biological Chemistry 279 48930 -48940

[9] CangulH,SalnikowK,YeeH, 2002.Enhanced expression of a novel protein in human cancer cells : a potential aid to cancer diagnosis,Cell Biol Toxicol 18 87296 -

[10] HeJ,Zhou R L., 2003.Correlation of NDRG1 gene with liver tissue diefrentiation and hepatocarcinogenesis,Journal of Peking University( health sciences) 35 471 -475

[11] FerrarN,HenzelW J, 1989.Pituitary follicular cell secrete a novel heparin- binding growth factors specific for vascular endothelial cells,Biochemical and Biophysical Research Communications 161 851 -857

[12] 2000.67 protein: fascinating forms and an unknown function,Exp Cell Res 257 231 -237

Citations

Downloads

Views