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A study of the photostability of ergocalciferol (Vitamin D2) in organic solvents.
Author(s):
1. Tauqir Ahmad: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
2. Iqbal Ahmad: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
3. Arshad Majeed: Pharmaceutical Chemistry Department, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan
Abstract:
The photolysis of ergocalciferol (vitamin D2) in several organic solvents has been studied to determine the influence of solvent dielectric constant and viscosity on the rate of reaction. Ergocalciferol degrades by zero-order kinetics and the rate constants vary from 0. 74x10-5 mol 1-1 (methanol) to 1. 56 x 10-5 mol 1-1 (chloroform). The rates appear to be a linear function of the reciprocal of dielectric constant and viscosity of the medium in the range studied.
Page(s): 1-7
DOI: DOI not available
Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 6, Issue: 2, Year: 1993
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