XPG is a novel biomarker of clinical outcome in advanced non-small-cell lung cancer. | [Pakistan Journal of Medical Sciences • 2013]

Author(s):

1. Yi Yuli: Nursing College of Nanchang University, Nanchang, China

2. Sun Zhe: Department of Oncology, the First Affiliated Hospital of Nanchang, University, Nanchang, China

3. Wang Xia: The Fourth Department of Tuberculosis, The First Affiliated Hospital, Xinxiang Medical College, Weihui, China

4. Li Siqing: The First Affiliated Hospital, Xinxiang Medical College, Weihui, China

5. Wu Zhenxuan: The First Affiliated Hospital, Xinxiang Medical College, Weihui, China

6. Zhu Yu-Hua: The First Affiliated Hospital, Xinxiang Medical College, Weihui, China

7. Sun Bing: The First Affiliated Hospital, Xinxiang Medical College, Weihui, China

8. Cui Jun-Wei: The First Affiliated Hospital, Xinxiang Medical College, Weihui, China

Abstract:

Objective: Polymorphisms in XPG were considered to contribute to the clinical outcome of patients receiving platinum drug chemotherapy. We investigated the impact of several potential SNPs of XPG on the efficacy of platinum-based chemotherapy in NSCLC patients. Methodology: A total of 433 patients were consecutively selected between Nov. 2006 and Dec. 2007, and were followed-up up to Nov. 2011. The genotyping of six SNPs (rs2296147, rs751402, rs873601, rs4150375,rs17655 and rs2094258) were genotyped using the Taqman real-time PCR method with a 7900 HT sequence detector system. Results: Patients carrying CT+TT genotype of rs2296147 had a significantly longer median PFS (17.5 months) and OS (26.8 months) than CC genotype. Hazard ratio (HR) for PFS and OS in patients with CT+TT genotype of rs2296147 was respectively 0.73(0.51-0.97) and 0.66(0.48-0.99) when compare CC genotype, respectively. Similarly, patients with rs2094258 AG+GG genotype had a longer median progression time (18.4 months) and overall survival time (27.3 months) when compared with those with AA genotype, and HRs(95% CI) for PFS and OS were 0.44(0.34-0.78) and 0.51(0.39-0.82), respectively. Conclusions: Our study suggests rs2296147 CT+TT and rs2094258 AG+GG genotypes contribute to the better survival of NSCLC. Our study provides significant information on role of prognostic value of XPG SNPs, and detecting of XPG could be used as predictive markers toward individualizing NSCLC treatment strategies.

Page(s): 762-767

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 29, Issue: 3, Year: 2013

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