Abstract:
Metformin is one of the most commonly used drugs in the treatment of type 2 diabetes mellitus. It is the only biguanide class that is still used as an oral hypoglycemic drug. Metformin works to reduce blood glucose levels by increasing glucose transport into muscle cells. This drug can increase glucose uptake by up to 10-40%. The effect of administering metformin on GFR values and lactic acidosis condition in patients with impaired renal function. This review was conducted by extracting data from PubMed, Google Scholar, ScienceDirect. The articles related to metformin, kidney disease, and lactic acidosis in English-language in 2010 to July 2020. Article that been selected are based on inclusion and exclusion. Although renal metformin was cleared, drug levels generally remained within the therapeutic range, and lactate concentrations did not increase substantially when used in patients with mild to moderate chronic kidney disease (estimated glomerular filtration rate of 30-60 ml/min / 1.73 m2). The Data shows an increased risk of lactic acidosis in patients treated with metformin with severe chronic kidney disease, with a GFR value <30 ml/min / 1.73 m2. Available evidence supports the careful use of metformin for use in patients with mild to moderate chronic kidney disease.
Page(s):
533-538
DOI:
DOI not available
Published:
Journal: Science International, Volume: 32, Issue: 5, Year: 2020
Keywords:
GFR
,
Kidney disease
,
side effects
,
Lactic acidosis