Valuing Best Poloxamer Carrier for Meloxicam Solid Dispersions by novel microwave fusion: Designing and Characterization | [Abasyn Journal of Life Sciences • 2019]

Author(s):

1. Keerthi S: Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India

2. Rajeshpawan A: Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India

3. Hindustan Abdul Ahad: Department of Industrial Pharmacy, Raghavendra Institute of Pharmaceutical Education and Research (RIPER)-Autonomous, K.R.Palli Cross, Ananthapuramu 515721, AP, India.

4. Naveena C: Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India

5. Yuvasree S: Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India

6. Venkataramana V: Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India

7. Raghu U: Jawaharlal Nehru Technological University-OTPRI, Ananthapuramu 515001, AP, India

Abstract:

Present research activity is to establish the best Poloxamer carriers for making solid dispersions (SD) with Meloxicam. The main aim of this investigation is to find the best among the better Poloxamer carriers viz., Poloxamer-108, Poloxamer-188, Poloxamer-237, Poloxamer-338 and Poloxamer-407 for making SD by novel microwave fusion technique. Four portions of Meloxicam: Poloxamer in various ratios (1:1, 1:2, 1:4 and 1:6) are used for making SD by microwave fusion technique later compressed using 8 station tablet compression machine. The SD and tablet formulations are evaluated for physicochemical characterization. All the prepared batches found to have satisfactory specifications as per pharmacopoeia. The authors concluded that Poloxamer-188 is found to be the best carrier among the Poloxamer carriers used for making Meloxicam SD.

Page(s): 1-15

DOI: DOI not available

Published: Journal: Abasyn Journal of Life Sciences, Volume: 2, Issue: 1, Year: 2019

Keywords:

tablets , Meloxicam , microwave , solid dispersions , Poloxamer

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