The possible protective role of HLA B27 and relevant immune markers in Juvenile Idiopathic Arthritis patients | [Pakistan Journal of Medical Sciences • 2024]

Author(s):

1. Farhana Shahzad: Immunology Department, University of Health Sciences (UHS), Lahore - Pakistan.

2. Romeeza Tahir: Immunology Department, University of Health Sciences, Lahore, Pakistan.

3. Faheem Shahzad: University of Health Sciences, Lahore, Pakistan.

4. Nadeem Afzal: Immunology Department, Akhtar Saeed Medical College, Lahore, Pakistan.

Abstract:

Background & Objectives: JIA is a disease with diferent immunological characteristics and a complicated genetic foundation. HLA B27 is a risk factor for the development of JIA, and its impact on immunopathogenesis of the disease is also an area of interest. To determine whether HLA B27 and immune markers varied between JIA patients and healthy population. Methods: This comparative cross-sectional study was conducted at Immunology Department of University of Health sciences (UHS), Lahore from February 2018 till August 2021. A total of (71) JIA patients and (34) healthy controls were enrolled. B cells were enumerated by flowcytometry, ELISA was used for serum cytokines estimation and HLA B27 allele was detected by SPSS polymerase chain reaction. Results: The HLA B27 allele was significantly more in the control group than in the patient group, suggesting it is a protective allele to prevent JIA. Peripheral blood B cell counts and percentages were significantly lower in the HLA B27 positive group than in the HLA B27 negative group of control population. Serum cytokine levels were not significantly diferent between the HLA B27 positive and HLA B27 negative allele of the two study populations. Conclusion: In this study B cells are diferent between the two groups of control population however; serum cytokines are comparable between the study groups. Though, it was indicated that HLA B27 may be a preventive allele in the onset of JIA.

Page(s): 835-840

DOI: 10.12669/pjms.40.5.7915

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 40, Issue: 5, Year: 2024

Keywords:

Cytokines , JIA , HLA B27 , B cells

References:

References are not available for this document.

Citations

Citations are not available for this document.

Citations

Downloads

Views