Abstract:
Recent technological advancement and expanded efforts have led to a tremendous growth in the collective knowledge of the human microbiome. The gut microbiome has been connected with human health and disease including all those affecting the brain. Abnormalities in this microbiota gut brain axis have emerged as a significant component in the pathophysiology of depression, prompting exploratory research into the neuroactive potential of gut microbial metabolic products. Over the last decade, research has revealed a plethora of complicated interactions between the microbiota and the immunological and metabolic systems, many of which have important consequences for human health. In present study, we emphasize accumulating evidence suggesting the microbiome exerts effect on the brain via multiple routes linking the stomach to the central nervous system. While knowledge of the influence of gut bacteria on neurological function is still developing, understanding the gut-microbiome brain links has the potential to transform neuroscience by discovering possibly new etiologies for mental and neurodegenerative diseases. Overall, our results show that patients with diverse brain disorders have changed bacterial metabolites, as well as the possible neuroactive effects of gut-derived SCFAs, p-cresol, serotonin derivatives, and bacterial amyloids on disease onset and progression. The results of this study might lead to more understanding of the gut-brain axis and, as a response, to possible diagnostic, therapeutic, or preventative measures for brain disorders.
Page(s):
16-24
DOI:
DOI not available
Published:
Journal: Frontiers in Chemical Sciences, Volume: 3, Issue: 1, Year: 2022
Keywords:
Probiotic
,
Lipopolysaccharides
,
Brain diseases
,
SCFAs
,
Gut metabolites