The hepato-protective effect of cassia fistula (amaltas) leaves in isonlazid and rifampicin induced hepatotoxicity in rodents. | [Biomedica • 2010]

Author(s):

1. Adnan Jehangir: Department of Pharmacology and Pathology, University of Health Sciences, Lahore and Rawalpindi Medical College, Pakistan

2. A. H. Nagi: Department of Pharmacology and Pathology, University of Health Sciences, Lahore and Rawalpindi Medical College, Pakistan

3. M. Shahzad: Department of Pharmacology and Pathology, University of Health Sciences, Lahore and Rawalpindi Medical College, Pakistan

4. Zia Azam: Department of Pharmacology and Pathology, University of Health Sciences, Lahore and Rawalpindi Medical College, Pakistan

Abstract:

Certain medicinal plants have been reported to have their effect on various experimentally induced diseases. Drug induced hepatitis (DIH) is one of thorn. The purpose of this study teas to assess the of IM ol`etharrolc extract ofCassia stula leaves in experimentally induced drug hepatitis (DIH) in rodents. The rats were divided into four groups, i.e. a control group (A), antituberculous (ATT) group groups (B), and the remaining two (C and D) served as experimental therapy groups. They received Cassia fistula extract as hepatoprotective agent. Rats having normal liver functions were included in this study. Group C experimental rats received (INH/RIF) (50 mg/kg) each and ethanolic extract of Cassia fistula at 400 mg/kg of body weight. On the other hand group D experimental rats received (INH/RIF) (50 mg/kg) each and ethanolic extract of Cassia fistula at 500 mg/kg of body weight. Blood samples were taken at 30th day and liver in each was taken out for microscopical examination on day 30th. The (ATT) group rats showed variable increase in serum ALT, AST, ALP and total bilirubin levels. Group C treated with 400 mg/kg of body weight Cassia fistula treatment decreased the level of these parameters in rats. On the other hand group D ruts treated with 500 mg/kg body weight of Cassia fistula dose significantly decreased levels of these biochemical parameters. The morphological examination of experimental group C rats showed slight recovery. Cassia fistula constituents, expecially flavonoids and anthraquinones have strong anti-oxidant activity which provides hepato-protection against drug-induced hepatitis (DIH). In conclusion, high dose of Cassia fistula ethanolic leves extract (500 mg/kg) body weight showed hepato- protection against INH/RIF induced hepatitis in rats.

Page(s): 25-29

DOI: DOI not available

Published: Journal: Biomedica, Volume: 26, Issue: 1--6, Year: 2010

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