Validity of C-reactive protein (CRP) for diagnosis of neonatal sepsis. | [Pakistan Journal of Medical Sciences • 2015]

Author(s):

1. Effat Hisamuddin: Tehsil Headquarter Hospital (THQ), Chakdara, Khyber Pakhtunkhwa, Pakistan

2. Aliya Hisam: Community Medicine Department, National University of Sciences and Technology (NUST), Army Medical College, Rawalpindi, Pakistan

3. Sughra Wahid: Kahuta Research Laboratories (KRL) Hospital, Islamabad, Pakistan

4. Ghulam Raza: Army Medical College, Rawalpindi, Pakistan

Abstract:

Objective: To determine the validity of C-reactive protein levels for diagnosis of neonatal sepsis. Methods: A cross sectional (Validation) study was conducted at Neonatology unit in KRL general hospital (emergency/OPD) of 7 months duration from February 2012 to August 2012. By using purposive sampling technique, 147, sample size was calculated by using WHO sample size calculator taking sensitivity 75%, specificity 95%, expected prevalence 50%, desired precision 10% and confidence level 95%. Results: Mean age of the neonates was 5. 72 days + 3. 86. Male patients were 81(55. 1%) while 66(44. 9%) were female. Neonatal sepsis was observed in 43(29. 25%) and were confirmed through blood culture while 104(70. 75%) were not confirmed on blood culture as neonatal sepsis. The sensitivity and specificity of CRP in diagnosis of acute neonatal sepsis was 76. 92% and 53. 49% respectively while it had a positive predictive value of 80% and negative predictive value of 48. 94%. Over all the diagnostic accuracy of CRP in diagnosis of neonatal sepsis was 70. 07%. Conclusion: CRP estimation does have a role in the diagnosis of neonatal sepsis but the test is not specific enough to be relied upon as the only indicator.

Page(s): 527-531

DOI: DOI not available

Published: Journal: Pakistan Journal of Medical Sciences, Volume: 31, Issue: 3, Year: 2015

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