Abstract:
-Urinary tract infections (UTI) are among the most commonly occurring infections, affecting 150 million people annually, and a mortality rate of 20-40% per year. Traditionally, Grewia asiatica (Phalsa) is used as a summer fruit for its stimulant and coolant effect. This study is carried out to investigate the anti-uropathogenic activity of G. asiatica and formulation of its fruit powder sachets as alternative to treat UTI. The antiuropathogenic activity of the G. asiatica aqueous and organic extractswere evaluated against uropathogenic bacterial strains by the disc diffusion method. The extracts were evaluated for its antioxidant activity through DPPH free radical scavenging assay. In addition, the extracts were further evaluated for its cytotoxic potential on normal Human Corneal Epithelial cells (HCEC). G. asiatica fruit extracts exhibited antiuropathogenic activity against uropathogenic strains including, Escherichia coli, Acinetobacter baumanii, Staphylococcus aureus, Proteus mirabilis, and Pseudomonas aeruginosa. In addition, the fruit extract exhibited strong radical scavenging activity at a concentration of 500 µg/ml. Furthermore the G. asiatica fruit extracts showed low cytotoxicity against HCEC cell line. The G. asiatica fruit extracts revealed the presence of secondary metabolites and showed the anti-uropathogenic activity with low cytotoxicity to normal cells, therefore this study can provide the basis for the formulation of dry powder sachet from Phalsa as an alternative therapy to treat UTI.
Page(s):
0-0
DOI:
DOI not available
Published:
Journal: First International Conference on Revamped Scientific Outlook of 21st Century (Abstract Book), Volume: 0, Issue: 0, Year: 2022