A study on the correlation between preoperative vitamin D levels and postoperative pain and quality of life in middle-aged and young patients with lumbar degenerative diseases | [Pakistan Journal of Pharmaceutical Sciences • 2025]

Author(s):

1. Lingling Cui: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

2. Jin Zhou: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

3. Yu Qin: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

4. Yiqin Yang: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

5. Zhihui Yu: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

6. Xiaomei Chen: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

7. Huiling Yue: Nursing Department, Shanghai Sixth People's Hospital,Shanghai,China

Abstract:

To investigate the correlation between preoperative vitamin D levels and postoperative pain and quality of life in young and middle-aged patients with lumbar degenerative disease (LDD). The 228 young and middle-aged LDD patients treated in Shanghai Sixth People's Hospital (China) between January 2022 and December 2023 were chosen for the research. The patients were categorized into an insufficient/deficient group as well as an adequate group on the basis of 25-(OH)D levels. Visual analogue scale (VAS), Japanese Orthopaedic Association (JOA) score, Oswestry disability index (ODI), and quality of life score (SF-12) of the two groups were compared, respectively. To assess the correlation between preoperative vitamin D and postoperative pain and quality of life in LDD patients. Preoperative 25-(OH)D was positively correlated with postoperative lumbar spine function and life quality, and negatively correlated with postoperative pain and ODI index (P<0.05). The results of multiple linear regression analysis showed that the serum 25(OH)D level was the main influencing factor for postoperative pain and quality of life in patients with LDD. For every 1ng/mL increase in 25-(OH)D level, the VAS score decreased by 0.091 points and the quality of life score increased by 0.349 points. The lower the preoperative serum vitamin D level in LDD patients, the higher the risk of postoperative pain, the more serious the dysfunction of patients, and the worse the quality of life.

Page(s): 795-801

DOI: 10.36721/PJPS.2025.38.3.REG.13653.1

Published: Journal: Pakistan Journal of Pharmaceutical Sciences, Volume: 38, Issue: 3, Year: 2025

Keywords:

Vitamin D , Postoperative pain , Quality of life , lumbar degenerative disease

References:

[1] Amrein K,Scherkl M,Hoffmann M,NeuwerschSommeregger S,Kostenberger M,Tmava Berisha A,Martucci G,Pilz S,Malle O .2020 .Vitamin D deficiency 2.0: An update on the current status worldwide. Eur. J. Clin. Nutr, 74(11) : 1498-1513.

[2] Aoki Y,Takahashi H,Nakajima A,Kubota G,Watanabe A,Nakajima T,Eguchi Y,Orita S,Fukuchi H,Yanagawa N,Nakagawa K,Ohtori S K .2020 .Prevalence of lumbar spondylolysis and spondylolisthesis in patients with degenerative spinal disease. Sci. Rep, 10(1) : 6739.

[3] Arovah NI,Heesch KC .2021 .Assessment of the validity and reliability of the Indonesian version of Short Form 12 (SF-12). J. Prev. Med, 62(2) : E421-E429.

[4] Aytekin E,Ozgonenel L,Coskun H,Dede BT,Demir SE .1992 .Use of the Oswestry Disability Index in ankylosing spondylitis. Rev. Assoc. Med, 69(12) : e20230927.

[5] Baek W,Park SY,Kim Y .2023 .Impact of frailty on the outcomes of patients undergoing degenerative spine surgery: A systematic review and meta-analysis. BMC. Geriatr., 23(1) : 771.

[6] Bajaj A,Shah RM,Goodwin AM,Kurapaty S,Patel AA,Divi SN .2023 .The Role of Preoperative Vitamin D in Spine Surgery. Curr. Rev. Musculoskelet. Med, 16(2) : 48-54.

[7] Bamps S,Raymaekers V,Roosen G,Put E,Vanvolsem S,Achahbar SE,Meeuws S,Wissels M,Plazier M M .2023 .Lateral lumbar interbody fusion (Direct Lateral Interbody Fusion/Extreme Lateral Interbody Fusion) versus Posterior Lumbar Interbody Fusion Surgery in Spinal Degenerative Disease: A systematic review. World. Neurosurg., 171 : 10-18.

[8] Biczo A,Szita J,McCall I,Varga PP,Genodisc Consortium Lazary A .2022 .Association of vitamin D receptor gene polymorphisms with disc degeneration. Eur. Spine. J., 29(3) : 596-604.

[9] Bogaert L,Thys T,Depreitere B,Dankaerts W,Amerijckx C,Van Wambeke P,Jacobs K,Boonen H,Brumagne S,Moke L,Schelfaut S,Spriet A,Peers K,Swinnen TW,Janssens L TW .2022 .Rehabilitation to improve outcomes of lumbar fusion surgery: A systematic review with meta-analysis. Eur. Spine. J., 31(6) : 1525-1545.

[10] Chang SW,Lee HC .2019 .Vitamin D and health - The missing vitamin in humans. , 60(3) : 237-244.

[11] Holick Charoenngam N,MF Charoenngam N .2097 .Immunologic effects of vitamin D on human health and disease. Nutrients., 12(7) : .

[12] Dechsupa S,Yingsakmongkol W,Limthongkul W,Singhatanadgige W,Jitjumnong M,Honsawek S M .2023 .Vitamin D inadequacy affects skeletal muscle index and physical performance in lumbar disc degeneration. Int. J. Mol. Sci, 24(4) : 3152.

[13] Speeckaert Delrue C,MM Delrue C .2023 .Vitamin D and vitamin D-binding protein in health and disease. Int. J. Mol. Sci, 24(5) : 4642.

[14] Donnally CJ,Sheu JI,Bondar KJ,Mouhanna JN,Li DJ,Butler AJ,Rush AJ,Gjolaj JP .2019 .Is there a correlation between preoperative or postoperative vitamin D levels with pseudarthrosis, hardware failure, and revisions after lumbar spine fusion. , 130 : e431-e437.

[15] Fang F,Chai Y,Wei H,Wang K,Tan L,Zhang W,Fan Y,Li F,Zhu Shan Z,M Shan Z .2021 .Vitamin D deficiency is associated with thyroid autoimmunity: Results from an epidemiological survey in Tianjin, China. , 73(2) : 447-454.

[16] Fleet JC .2022 .Vitamin D-mediated regulation of intestinal calcium absorption. Nutrients, 14(16) : 3351.

[17] Hauser RA,Matias D,Woznica D,Rawlings B,Woldin BA .2022 .Lumbar instability as an etiology of low back pain and its treatment by prolotherapy: A review. J. Back. Musculoskelet. Rehabil., 35(4) : 701-712.

[18] Hiyama A,Katoh H,Nomura S,Sakai D,Sato M,Watanabe M M .2022 .Treatment of lumbar degenerative disease by lateral lumbar interbody fusion in patients under and over 80 years of age. , 167 : e747-e756.

[19] Hu MH,Tseng YK,Chung YH,Wu NY,Li CH,Lee PY .2022 .The efficacy of oral vitamin D supplements on fusion outcome in patients receiving elective lumbar spinal fusion-a randomized control trial. BMC. Musculoskelet. Disord., 23(1) : 996.

[20] Kato S,Oshima Y,Oka H,Chikuda H,Takeshita Y,Miyoshi K,Kawamura N,Masuda K,Kunogi J,Okazaki R,Azuma S,Hara N,Tanaka S,Takeshita K S .2015 .Comparison of the Japanese Orthopaedic Association (JOA) score and modified JOA (mJOA) score for the assessment of cervical myelopathy: A multicenter observational study. PLoS, 10(4) : e0123022.

[21] Khalooeifard R,Rahmani J,Tavanaei R,Adebayo O,Keykhaee M,Ahani A,Zali A,Shariatpanahi ZV,Oraee-Yazdani S .2022 .The effect of vitamin d deficiency on outcomes of patients undergoing elective spinal fusion surgery: A systematic review and metaAnalysis. Int. J. Spine. Surg., 16(1) : 53-60.

[22] Rojano-Ortega D,Berral-de la Rosa FJ .2023 .Effects of vitamin D supplementation on muscle function and recovery after exercise-induced muscle damage: A systematic review. J. Hum. Nutr, 36(3) : 1068-1078.

[23] Seijo M,Bonanno MN,Bryk G,Zeni Coronel ME,Pita Martin de Portela ML,Zeni SN .2022 .Does Vitamin D Insufficiency Influence Prebiotic Effect on Calcium Absorption and Bone Retention? Calcif. , 111(3) : 300-312.

[24] Shafshak TS,Elnemr R .2021 .The Visual Analogue Scale versus Numerical Rating Scale in Measuring Pain Severity and Predicting Disability in Low Back Pain. J. Clin. Rheumatol, 27(7) : 282-285.

[25] Stepanov IA,Beloborodov VA,Shameeva MA,Tomashov II,Saakyan ZS,Trepeznikov VG .2020 .Prevalence of Vitamin D Deficiency in Elderly Patients Planned for Spine Surgery. , 33(6) : 1193-1199.

[26] Tan ML,Abrams SA,Osborn DA .2020 .Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health. Cochrane. Database. Syst. Rev., 12(12) : CD013046.

[27] Xu HW,Shen B,Hu T,Zhao WD,Wu DS,Wang SJ .2020 .Preoperative vitamin D status and its effects on short-term clinical outcomes in lumbar spine surgery. J. Orthop. Sci., 25(5) : 787-792.

[28] Yasuhara T,Sasada S,Date I .2021 .Lumbar Degenerative Disease: Key for Diagnosis. , 49(6) : 1233-1245.

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